{"id":"W4387825294","doi":"10.1016/j.annonc.2023.09.2349","title":"1315MO Durable efficacy of zenocutuzumab, a HER2 x HER3 bispecific antibody, in advanced NRG1 fusion-positive (NRG1+) non-small cell lung cancer (NSCLC)","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Cilag; Foundation Medicine; Takeda Pharmaceuticals International; Ignyta; Loxo Oncology; Eli Lilly Japan; MSD K.K.; Chugai Pharmaceutical; Pfizer Japan; Novartis Pharma; EMD Serono; Grifols; Ipsen; PharmaMar; Sociedad Española de Oncología Médica; Japanese Society of Medical Oncology; Amgen Astellas Biopharma; Otsuka Pharmaceutical; Daiichi-Sankyo; Les Laboratories Pierre Fabre; Bayer HealthCare; Springworks Therapeutics; Relay Therapeutics; Sysmex Corporation; Helsinn; Mylan; Mirati Therapeutics; Daiichi Sankyo Europe; Takeda Oncology; European Society for Medical Oncology; Agios Pharmaceuticals; Jazz Pharmaceuticals; Kissei; Regeneron Pharmaceuticals; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Bayer Yakuhin; Verastem Oncology; Amgen; Ariad Pharmaceuticals; Ono Pharmaceutical; Takeda Pharmaceutical Company; FibroGen; Puma Biotechnology; Medpace; OncoMed Pharmaceutical; Boehringer Ingelheim Japan; Merck KGaA; Gilead Sciences; Taiho Pharmaceutical; F. Hoffmann-La Roche; Celgene; Yuhan; Mersana Therapeutics; Merck Sharp and Dohme; Spectrum Pharmaceuticals; Barbara Ann Karmanos Cancer Institute; Eli Lilly and Company; Novocure; Genentech; International Association for the Study of Lung Cancer; AstraZeneca; American Society of Clinical Oncology; Daiichi Sankyo Company; BeiGene; Astellas Pharma; Eisai; Pharmacyclics; Pfizer Pharmaceuticals; Exelixis; Sanofi; Servier; Incyte; Pfizer","keywords":"Medicine; non-small cell lung cancer (NSCLC); Lung cancer; Oncology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002939916,0.0003413019,0.0008021348,0.0001582239,0.0002201376,0.0004181309,0.0003060656,0.000433133,0.002590518],"category_scores_gemma":[0.0001982143,0.0001427364,0.0005078129,0.0002000524,0.0002689873,0.0003211572,0.0001448454,0.001058446,0.0005513109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921894,"about_ca_system_score_gemma":0.0005187253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001896776,"about_ca_topic_score_gemma":0.005535579,"domain_scores_codex":[0.999897,0.00001771229,0.000005139417,0.00001427006,0.00001442847,0.00005140052],"domain_scores_gemma":[0.9999105,0.00001550319,0.00001128665,0.00001057569,0.000005984964,0.00004610766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1692312,0.01540198,0.0149267,0.0007985529,0.001607212,0.001793655,0.0003063104,0.005857996,0.277884,0.001418756,0.01160035,0.4991733],"study_design_scores_gemma":[0.1045151,0.5016515,0.1980111,0.0001836239,0.00244957,0.005858263,0.0002527513,0.0136622,0.1221094,0.001012648,0.05015111,0.0001428238],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929476,0.002678664,0.000225789,0.0003064695,0.0001243501,0.00006791504,0.0003695048,0.00009706509,0.00318252],"genre_scores_gemma":[0.9952742,0.0008768858,0.000188244,0.0002159284,0.00003878716,0.00002597823,0.000857626,0.00001487483,0.002507502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590518,"threshold_uncertainty_score":0.008666098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03218767099273469,"score_gpt":0.416854446127853,"score_spread":0.3846667751351183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}