{"id":"W4387825797","doi":"10.1016/j.annonc.2023.09.506","title":"310P Longitudinal evaluation of circulating tumour DNA in early breast cancer using a plasma-only methylation-based assay","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"GlaxoSmithKline (Canada); Royal Victoria Regional Health Centre; Princess Margaret Cancer Centre; University Health Network","funders":"Seagen; Sanofi; Servier; Princess Margaret Cancer Foundation; Amgen; Pfizer; Genentech; American Association for Cancer Research; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Internal medicine; Breast cancer; Oncology; Cancer; Triple-negative breast cancer; Minimal residual disease; Perioperative; Gastroenterology; Surgery; Leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007521556,0.0003240803,0.0002851678,0.0008103394,0.000355026,0.0005677149,0.000365272,0.0006417696,0.001181764],"category_scores_gemma":[0.001979921,0.0003099816,0.0001671264,0.0006140299,0.0002335691,0.0003044855,0.0003508013,0.0007022347,0.0005579691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003418381,"about_ca_system_score_gemma":0.0003480822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0020741,"about_ca_topic_score_gemma":0.00209473,"domain_scores_codex":[0.9993908,0.0001450121,0.00002203597,0.0001790867,0.0001984064,0.00006460174],"domain_scores_gemma":[0.9992693,0.0002344332,0.0001261907,0.00005620765,0.0002115699,0.0001023706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002452416,0.0002655151,0.6221685,0.00009825726,0.000144191,0.0005592383,0.0005509074,0.0007948602,0.3257241,0.0002567781,0.001058304,0.04592692],"study_design_scores_gemma":[0.00007356185,0.0025477,0.8230001,0.00003378265,0.0002200975,0.00518831,0.0003595602,0.008024983,0.1548618,0.0005441213,0.005099026,0.00004691129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988542,0.0008355802,0.00660687,0.0002084652,0.00003234799,0.00003937806,0.001672886,0.0002143129,0.001848257],"genre_scores_gemma":[0.9932247,0.0002212248,0.003694655,0.0001201668,0.0000190217,0.00005408861,0.0009253391,0.00002582273,0.001714939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0020741,"threshold_uncertainty_score":0.004124105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1167992649650372,"score_gpt":0.4048033611204578,"score_spread":0.2880040961554206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}