{"id":"W4387826531","doi":"10.1016/j.annonc.2023.09.1140","title":"1910P Evaluation of a genome-wide methylome enrichment platform for circulating tumor DNA quantification and prognostic performance in renal cell carcinoma (RCC)","year":2023,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Renal cell carcinoma; DNA methylation; Genome; Oncology; Cancer research; Gene; Genetics; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009190597,0.000451494,0.0004510487,0.0007160928,0.0003700171,0.0006469699,0.0004169676,0.0005604022,0.002838902],"category_scores_gemma":[0.001310352,0.0002504576,0.0003956587,0.0005253514,0.0001946278,0.000203287,0.000644796,0.0004995958,0.0006767372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297822,"about_ca_system_score_gemma":0.0005302881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002272243,"about_ca_topic_score_gemma":0.003925215,"domain_scores_codex":[0.9995135,0.00006301387,0.00001883076,0.0001761963,0.0001599193,0.0000685283],"domain_scores_gemma":[0.9996309,0.0001325414,0.00006857047,0.0000312303,0.00008645178,0.00005041187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004120041,0.000313207,0.1950034,0.0003692471,0.0007639513,0.0005785744,0.0002379436,0.003304206,0.6693802,0.0006534964,0.003388208,0.1218875],"study_design_scores_gemma":[0.0005442903,0.002602093,0.5785458,0.000128403,0.002070407,0.002800836,0.000217053,0.04262647,0.3537787,0.001545102,0.01499976,0.0001410138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831117,0.001887626,0.005638306,0.0005129204,0.00009761178,0.00006788047,0.006288809,0.0003348753,0.002060184],"genre_scores_gemma":[0.9867661,0.0003407191,0.006538578,0.0003109663,0.00003727105,0.0001105583,0.004022484,0.00006070043,0.001812545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002838902,"threshold_uncertainty_score":0.009497106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09279231915420123,"score_gpt":0.3510396802693599,"score_spread":0.2582473611151587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}