{"id":"W4387844111","doi":"10.1002/cmdc.202300458","title":"Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication","year":2023,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Xenon Pharmaceuticals (Canada); Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Proteases; Protease; Peptidomimetic; Virus; Influenza A virus; Virology; Serine protease; Biology; Transmembrane protein; Antiviral drug; Viral replication; Biochemistry; Enzyme; Receptor; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518563,0.0003951096,0.0002696457,0.0001381888,0.00008746112,0.0002077046,0.0002591402,0.000171856,0.0008983257],"category_scores_gemma":[0.0001202726,0.0001204412,0.0001657212,0.0001582727,0.00009981584,0.0001502877,0.0001101629,0.0003076219,0.0002097143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211607,"about_ca_system_score_gemma":0.0002196258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00073661,"about_ca_topic_score_gemma":0.001867242,"domain_scores_codex":[0.9998972,0.0000219914,0.00001073473,0.00001575166,0.00003271997,0.00002145709],"domain_scores_gemma":[0.9999576,0.000006721849,0.00001589051,0.00000240324,0.000006786015,0.00001069542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005638879,0.0001542109,0.000186539,0.0001079754,0.00001767227,0.00007984587,0.00001426953,0.001326167,0.9928939,0.0001081585,0.00007622158,0.004471193],"study_design_scores_gemma":[0.0002436698,0.003494696,0.002264854,0.0000109012,0.00006377237,0.0002344709,0.00001971328,0.003632033,0.9852986,0.00004226713,0.004677162,0.00001772375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923999,0.002818375,0.00230912,0.00006617008,0.0000304289,0.00008790782,0.0002611794,0.00004586375,0.001981058],"genre_scores_gemma":[0.9928359,0.002055519,0.003861788,0.00003377516,0.000009354634,0.00004578843,0.0002293348,0.00001209161,0.0009164431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008983257,"threshold_uncertainty_score":0.003005207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08750751580564103,"score_gpt":0.3752864016158706,"score_spread":0.2877788858102295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}