{"id":"W4387844111","doi":"10.1002/cmdc.202300458","title":"Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication","year":2023,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Xenon Pharmaceuticals (Canada); Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Proteases; Protease; Peptidomimetic; Virus; Influenza A virus; Virology; Serine protease; Biology; Transmembrane protein; Antiviral drug; Viral replication; Biochemistry; Enzyme; Receptor; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005507676,0.000247476,0.0004319405,0.0003981844,0.0001509741,0.00001223324,0.0001746761,0.0001535854,0.0001516257],"category_scores_gemma":[0.001509433,0.0002312452,0.0001120287,0.002023122,0.0001162977,0.00009928236,0.0001306323,0.0002521795,0.0001364124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200922,"about_ca_system_score_gemma":0.0002702804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008578091,"about_ca_topic_score_gemma":0.000006427052,"domain_scores_codex":[0.9977915,0.00003432219,0.0005532248,0.0005150227,0.0006557176,0.0004502186],"domain_scores_gemma":[0.9979649,0.00007516271,0.0001309368,0.0008594494,0.0006786352,0.0002909085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001471178,0.0003127407,0.001180552,0.0008763781,0.0001112157,0.00001774712,0.0008646522,0.01775302,0.9665302,0.00002279659,0.007031719,0.003827796],"study_design_scores_gemma":[0.001914797,0.0004511781,0.001809956,0.0002427927,0.0000574683,0.000003524957,0.00008890859,0.006755462,0.9762311,0.000006947456,0.01223208,0.0002057813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916325,0.0001893282,0.0001763061,0.003253347,0.00009096154,0.002011102,0.00003769494,0.0004178658,0.002190962],"genre_scores_gemma":[0.9921699,0.0001015876,0.003851895,0.002030704,0.0002525865,0.0004619163,0.0001548232,0.00009586,0.0008807308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01099756,"threshold_uncertainty_score":0.9429907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08750751580564103,"score_gpt":0.3752864016158706,"score_spread":0.2877788858102295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}