{"id":"W4387844227","doi":"10.1016/j.prp.2023.154902","title":"New emerging targets in osteosarcoma therapy: PTEN and PI3K/Akt crosstalk in carcinogenesis","year":2023,"lang":"en","type":"review","venue":"Pathology - Research and Practice","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"PTEN; PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Carcinogenesis; Downregulation and upregulation; Gene silencing; Biology; Osteosarcoma; Cancer; Medicine; Cell biology; Phosphorylation; Internal medicine; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005141677,0.0004272726,0.0009076611,0.0009365924,0.0001869354,0.0001348355,0.0004543056,0.0009550267,0.00003755826],"category_scores_gemma":[0.003485678,0.0003702333,0.0001196121,0.00105368,0.0003011153,0.00002389417,0.001047983,0.001654099,0.00003650528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009848329,"about_ca_system_score_gemma":0.001111421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010813,"about_ca_topic_score_gemma":0.001211217,"domain_scores_codex":[0.9933097,0.003146364,0.0005739529,0.001303796,0.0004995311,0.001166592],"domain_scores_gemma":[0.9976055,0.001018779,0.0001667094,0.0006839698,0.0002075075,0.0003175464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005779185,0.0001087763,0.00003625374,0.001896992,0.000171015,0.002741117,0.0002587842,0.000001416546,0.008854743,0.00009166861,0.0006121741,0.9846491],"study_design_scores_gemma":[0.001210712,0.0008053174,0.00005977871,0.0008518596,0.00004529645,0.001099218,0.000316366,0.000007453372,0.001094823,0.0003816342,0.9936773,0.0004502348],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007662991,0.9961501,0.0001776687,0.0005745682,0.000127933,0.001351336,0.00005332058,0.00001580125,0.0007829155],"genre_scores_gemma":[0.0004889405,0.9968075,0.0004569888,0.00006949462,0.0002179644,0.0003406242,0.0001906585,0.0001269872,0.001300904],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930651,"threshold_uncertainty_score":0.9998749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1626211394361916,"score_gpt":0.4772912555492051,"score_spread":0.3146701161130134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}