{"id":"W4387857029","doi":"10.1101/2023.10.22.563460","title":"Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; University of Toronto; Ted Rogers Centre for Heart Research; University Health Network","funders":"","keywords":"Induced pluripotent stem cell; Organoid; Fibroblast; Biology; Cardiac fibrosis; Population; Context (archaeology); Cell biology; Stem cell; Fibrosis; Cell type; Heart development; Cell; Pathology; Cell culture; Medicine; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042162,0.0002358413,0.0001305709,0.0001791065,0.00009495183,0.000317307,0.0002037863,0.0002755974,0.000400377],"category_scores_gemma":[0.0001620974,0.0001350726,0.0001955158,0.0001352283,0.0001655242,0.000114604,0.0002029192,0.0002547296,0.00009103978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849064,"about_ca_system_score_gemma":0.0001616641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007178,"about_ca_topic_score_gemma":0.001147435,"domain_scores_codex":[0.9999429,0.000009543972,0.000003418494,0.00001632355,0.00002151096,0.000006277088],"domain_scores_gemma":[0.9999423,0.00002462791,0.00001117284,0.000007822426,0.000007875294,0.000006135531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006590648,0.00003374312,0.002292854,0.00005488354,0.0000180637,0.00020593,0.00006116024,0.1582127,0.8328169,0.001457801,0.0001222181,0.004657837],"study_design_scores_gemma":[0.00002206818,0.0001647789,0.004324305,0.000009493019,0.00002486077,0.0001433199,0.00003976211,0.7170005,0.275401,0.0007274898,0.002126984,0.00001542878],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8708383,0.0002616061,0.1266466,0.00004909348,0.00001937237,0.000044749,0.0004040631,0.00009707576,0.001639123],"genre_scores_gemma":[0.9726088,0.000204543,0.02578642,0.00001970656,0.00000491578,0.00005015219,0.0003684111,0.00001959666,0.0009374262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007178,"threshold_uncertainty_score":0.002002656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0289614057401534,"score_gpt":0.2378415264194046,"score_spread":0.2088801206792512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}