{"id":"W4387865430","doi":"10.1158/2767-9764.crc-23-0289","title":"Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Center for Advancing Translational Sciences; Yale University; University of British Columbia; Roswell Park Cancer Institute","keywords":"Antigen; Carcinogenesis; Cancer; Immune system; Autoantibody; Antibody; Immunology; Biology; Retrotransposon; Clinical significance; Pancreatic cancer; Cancer research; Immunoassay; Medicine; Pathology; Genetics; Gene; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154207,0.0002129446,0.0001760122,0.0008007712,0.0003244758,0.0004290451,0.000122398,0.0003387969,0.001528118],"category_scores_gemma":[0.001242794,0.0001092008,0.00009322359,0.0003391448,0.000245501,0.0001575148,0.0001378295,0.0002868678,0.0002027338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002332612,"about_ca_system_score_gemma":0.0001009391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157869,"about_ca_topic_score_gemma":0.0006263554,"domain_scores_codex":[0.9997759,0.00006164064,0.00001353145,0.00008396825,0.00003737934,0.00002739137],"domain_scores_gemma":[0.9995609,0.0001697847,0.0001070529,0.00002968484,0.00006229498,0.00007034532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003708735,0.0000817786,0.9649836,0.00003693137,0.00006165901,0.0006443292,0.000179332,0.00008041406,0.01706759,0.0001506841,0.0005843631,0.01575844],"study_design_scores_gemma":[0.00001704553,0.0004408611,0.9867055,0.00001735629,0.00006756228,0.004362269,0.0001425697,0.0003340035,0.005099083,0.0002281293,0.002577092,0.000008610265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959777,0.001176628,0.000432813,0.0000957372,0.0000240086,0.000007754842,0.0001456525,0.00003482988,0.002104952],"genre_scores_gemma":[0.9994129,0.0001191576,0.0001434193,0.00005552012,0.00001899643,0.000002435321,0.00007953974,0.000002181328,0.0001659165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528118,"threshold_uncertainty_score":0.005112052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2301355727092511,"score_gpt":0.4345154980262343,"score_spread":0.2043799253169832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}