{"id":"W4387865472","doi":"10.1001/jamanetworkopen.2023.38995","title":"Testing and Management of Iron Overload After Genetic Screening–Identified Hemochromatosis","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Ted Rogers Centre for Heart Research; Hospital for Sick Children","funders":"","keywords":"Hemochromatosis; Medicine; Biobank; Hereditary hemochromatosis; Asymptomatic; Genetic testing; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009352526,0.0001253916,0.0001467724,0.000511253,0.0002594623,0.0003374504,0.0002546422,0.0003355333,0.0007089441],"category_scores_gemma":[0.003859389,0.00007101588,0.0001199551,0.0004628437,0.0001837196,0.0003379355,0.0002803994,0.0002886378,0.0001073559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888575,"about_ca_system_score_gemma":0.0003967064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002415776,"about_ca_topic_score_gemma":0.004131494,"domain_scores_codex":[0.9993955,0.0002120875,0.00006487814,0.00009043028,0.0001652484,0.00007175708],"domain_scores_gemma":[0.9984813,0.000299302,0.0009245919,0.00003907998,0.0001267615,0.0001288936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008685543,0.00006437275,0.989098,0.00003228972,0.00001682026,0.0003934913,0.0001635514,0.00006796524,0.0004755259,0.00002725776,0.0004958055,0.009078151],"study_design_scores_gemma":[0.000009345054,0.0002008783,0.9969895,0.00006970836,0.00001295542,0.001203779,0.0002712557,0.0003031966,0.0003356929,0.00007690608,0.0005228466,0.000004002256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9972141,0.0006886718,0.0002362134,0.0004354943,0.00001498626,0.00001883903,0.0002331626,0.000009485243,0.001149069],"genre_scores_gemma":[0.9990792,0.0002514594,0.0002241711,0.0001059138,0.00002037856,0.00001159838,0.0001325792,0.000001362227,0.0001733747],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002415776,"threshold_uncertainty_score":0.004946172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02656089191322944,"score_gpt":0.2803871024590914,"score_spread":0.253826210545862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}