{"id":"W4387865956","doi":"10.1080/1061186x.2023.2274804","title":"Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer","year":2023,"lang":"en","type":"article","venue":"Journal of drug targeting","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Mashhad University of Medical Sciences","keywords":"Nanocarriers; Epirubicin; Aptamer; Cytotoxicity; In vivo; Drug delivery; Cancer research; Cancer cell; Flow cytometry; Chemistry; Cell culture; Doxorubicin; Chemotherapy; MUC1; Cancer; Pharmacology; In vitro; Mucin; Medicine; Molecular biology; Biology; Biochemistry; Breast cancer; Biotechnology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003577621,0.0001356975,0.0002501473,0.0001227598,0.00006308782,0.00001668252,0.0001285671,0.00005275291,0.000011797],"category_scores_gemma":[0.0000640752,0.0001100589,0.00006075753,0.0002511102,0.00005067072,0.00001475535,0.00008357376,0.0001049416,0.000003761931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001753269,"about_ca_system_score_gemma":0.0001244169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001914231,"about_ca_topic_score_gemma":0.00002885877,"domain_scores_codex":[0.9989207,0.00005881163,0.000410792,0.0001696713,0.0001770384,0.0002629654],"domain_scores_gemma":[0.9990784,0.00002314793,0.0003047964,0.0001135573,0.0003530511,0.0001270393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003494162,0.00002887133,0.01598958,0.00002299814,0.00005979439,0.00002887203,0.0003875324,0.003726856,0.9758022,5.498362e-7,0.003437792,0.0001655748],"study_design_scores_gemma":[0.0007106307,0.0005152212,0.002121888,0.00009389422,0.00004347311,0.00003508494,0.001358096,0.0006506333,0.9937057,0.000002931517,0.0006141059,0.0001483755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979591,0.001511746,0.00007026058,0.00020651,0.0001166975,0.00007797124,0.00001212921,0.000005963165,0.00003960788],"genre_scores_gemma":[0.9981018,0.0002307722,0.001160438,0.0001856335,0.0001459898,0.000001173704,0.00000811957,0.00002263066,0.0001434062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0179035,"threshold_uncertainty_score":0.448807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01044232380264215,"score_gpt":0.2422436974398777,"score_spread":0.2318013736372356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}