{"id":"W4387866052","doi":"10.1007/s10571-023-01423-8","title":"In Vitro Models of Amyotrophic Lateral Sclerosis","year":2023,"lang":"en","type":"review","venue":"Cellular and Molecular Neurobiology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Faculté de Médecine, Université Laval; National Natural Science Foundation of China; Jiangxi Provincial Department of Science and Technology; Health and Family Planning Commission of Jiangxi Province; Education Department of Jiangxi Province; Université Laval","keywords":"Amyotrophic lateral sclerosis; SOD1; Pathogenesis; Neuroscience; Pathology; Biology; C9orf72; Medicine; Disease; Frontotemporal dementia; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002385835,0.0004583221,0.00240276,0.0006023661,0.00002939176,0.0000130382,0.0002528207,0.0006271487,0.00002907921],"category_scores_gemma":[0.00005465447,0.0003613609,0.0005037811,0.0005602852,0.00029017,0.00004435048,0.000376184,0.0007979489,0.00005136065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006041321,"about_ca_system_score_gemma":0.0001766885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007929761,"about_ca_topic_score_gemma":0.000001209046,"domain_scores_codex":[0.9971536,0.0004691357,0.0008210181,0.0007617754,0.0001926687,0.0006017828],"domain_scores_gemma":[0.9988779,0.0001002713,0.0001966082,0.0005731823,0.00006192774,0.0001900515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004076143,0.0004057543,0.000009028041,0.04943233,0.0008722249,0.004172685,0.0001104937,0.00003381676,0.78565,0.0008543141,0.0002800015,0.1577718],"study_design_scores_gemma":[0.01467649,0.005844655,0.0003938372,0.07519361,0.008136591,0.002440374,0.00002504479,0.002883946,0.0532999,0.005629664,0.8255047,0.005971251],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02123028,0.9770273,0.00005310665,0.0001343867,0.0001752691,0.001162953,0.00005509079,0.00004660802,0.0001150014],"genre_scores_gemma":[0.01188451,0.9869736,0.00008697015,0.0001713354,0.00006113116,0.00009408726,0.0002648263,0.0001344619,0.0003290048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8252246,"threshold_uncertainty_score":0.9998838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09441672300339947,"score_gpt":0.3255203342311307,"score_spread":0.2311036112277312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}