{"id":"W4387867132","doi":"10.1101/2023.10.20.563234","title":"A novel amphibian sex determination candidate gene, evolved by structural variation in the regulatory region between X and Y","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"University of Crete; Leibniz-Gemeinschaft; Leibniz-Institut für Gewässerökologie und Binnenfischerei; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Biology; Heterogametic sex; Genetics; Genome; Amphibian; Gene; Y chromosome; Evolutionary biology; Enhancer; Chromosome; Gene expression; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004365012,0.0001894248,0.0001240213,0.0002460808,0.0001616201,0.0001287071,0.0001541644,0.0002120016,0.001757917],"category_scores_gemma":[0.00005624233,0.00006802769,0.0001542236,0.0001237758,0.0001757607,0.00006851689,0.0001085826,0.0002496273,0.0002356677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243797,"about_ca_system_score_gemma":0.00009363252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004219957,"about_ca_topic_score_gemma":0.0007213854,"domain_scores_codex":[0.9999701,0.000002056451,0.000001496377,0.00001513882,0.000006394434,0.000004770657],"domain_scores_gemma":[0.9999651,0.000005380511,0.00001560562,0.000001958845,0.00000289313,0.000009105109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213203,0.00001370521,0.00840496,0.00006610089,0.00001433993,0.001596766,0.00005539525,0.0001264737,0.9816157,0.0003806545,0.0002021491,0.007402345],"study_design_scores_gemma":[0.00009424485,0.0004315007,0.4652845,0.0000528125,0.0001385517,0.01822426,0.0002280009,0.003677766,0.4813098,0.0007671759,0.02975538,0.00003603025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940342,0.0007469425,0.003193439,0.000109823,0.00002041792,0.00001338224,0.0007458072,0.0001117697,0.00102432],"genre_scores_gemma":[0.9938474,0.0002363467,0.002044848,0.0000640201,0.00001442499,0.00001081773,0.001026946,0.00002070809,0.002734464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757917,"threshold_uncertainty_score":0.005880833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689712542124583,"score_gpt":0.2385392930120564,"score_spread":0.2216421675908106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}