{"id":"W4387868975","doi":"10.3389/fendo.2023.1280847","title":"Developmental, cytogenetic and epigenetic consequences of removing complex proteins and adding melatonin during in vitro maturation of bovine oocytes","year":2023,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation; L'Alliance Boviteq","funders":"School of Biosciences, University of Nottingham; Biotechnology and Biological Sciences Research Council","keywords":"In vitro maturation; Germinal vesicle; Oocyte; Biology; Andrology; Blastocyst; Epigenetics; Melatonin; Ovarian follicle; DNA methylation; Follicular phase; Cell biology; Embryogenesis; Genetics; Embryo; Endocrinology; Gene expression; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004687168,0.000332449,0.0004508437,0.0002200872,0.0002562638,0.000509382,0.0003738564,0.0003158793,0.001408745],"category_scores_gemma":[0.0004298188,0.0002033033,0.0003050001,0.0001658382,0.0004475031,0.0002065294,0.0002601294,0.0007138971,0.0002101258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005661481,"about_ca_system_score_gemma":0.0005015312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625598,"about_ca_topic_score_gemma":0.003833627,"domain_scores_codex":[0.9992833,0.0001337967,0.00008276119,0.0001932327,0.000152779,0.0001541533],"domain_scores_gemma":[0.9993774,0.0001557758,0.0002276283,0.00003926556,0.00008041932,0.0001194157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002943629,0.0002227943,0.0006331941,0.00008572276,0.0000121982,0.00002471633,0.00006160069,0.00006077199,0.9944481,0.00002130833,0.00003340265,0.00145247],"study_design_scores_gemma":[0.0001574547,0.0149543,0.02674817,0.00002355609,0.000117079,0.00007871439,0.0001943361,0.0006228457,0.954809,0.00005767541,0.002211733,0.00002513602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977102,0.0008020431,0.000538315,0.00005291743,0.00005162642,0.00007488283,0.0002350723,0.00001122979,0.0005236459],"genre_scores_gemma":[0.9930601,0.0008100181,0.002553154,0.00009698568,0.00002742451,0.0002418987,0.0003942949,0.00001756081,0.0027986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625598,"threshold_uncertainty_score":0.00471276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778975444476638,"score_gpt":0.2698731783755622,"score_spread":0.2420834239307958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}