{"id":"W4387871074","doi":"10.21203/rs.3.rs-3459547/v1","title":"The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jacobs University; University of South Alabama; Swedish Orphan Biovitrum; Rheumatology Research Foundation; University of Ottawa; U.S. Department of Veterans Affairs","keywords":"NAD+ kinase; CD38; Inflammation; Chemistry; Gout; Pharmacology; Cancer research; Biochemistry; Cell biology; Medicine; Biology; Immunology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267945,0.0003472005,0.0002919139,0.0001917109,0.000155779,0.0004007505,0.0002145686,0.0002722,0.001704745],"category_scores_gemma":[0.00007855099,0.00009453886,0.0002129535,0.0001615341,0.0002556313,0.0002271064,0.0002405756,0.000604659,0.0002500542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153205,"about_ca_system_score_gemma":0.0002247401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002620449,"about_ca_topic_score_gemma":0.0005819549,"domain_scores_codex":[0.9999384,0.00000831255,0.000003472832,0.00001564232,0.00001589655,0.00001831176],"domain_scores_gemma":[0.9999603,0.00000460118,0.00001463372,0.000003678411,0.000006750166,0.000009961979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000860518,0.0001221163,0.0009220699,0.0005055743,0.00004200015,0.0001951556,0.00003126611,0.0003209029,0.9589767,0.001132528,0.0007382347,0.03615291],"study_design_scores_gemma":[0.0002561795,0.002581966,0.01040034,0.0001197718,0.0001517619,0.001393927,0.0001631304,0.002568315,0.911534,0.001620471,0.06917991,0.0000302143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8412229,0.1292783,0.01759486,0.002520615,0.0004126283,0.0002005629,0.001083236,0.0004630559,0.007223842],"genre_scores_gemma":[0.9714661,0.01925015,0.004749084,0.0002146324,0.0000836578,0.00008117443,0.0004104456,0.00001748863,0.00372727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704745,"threshold_uncertainty_score":0.005702972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03443645549017444,"score_gpt":0.3382171024136541,"score_spread":0.3037806469234797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}