{"id":"W4387871371","doi":"10.1021/acs.jmedchem.3c01273","title":"Dual Inhibition of <i>Mycobacterium tuberculosis</i> and the Host TGFBR1 by an Anilinoquinazoline","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; Genentech; Ontario Genomics; National Institutes of Health; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Boehringer Ingelheim; Takeda Canada; McGill University; National Institute of Allergy and Infectious Diseases; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Mycobacterium tuberculosis; Tuberculosis; Chemistry; Growth inhibition; In vitro; Drug resistance; Microbiology; Pharmacology; Biology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189246,0.0002842956,0.0002991046,0.0002048568,0.0001031337,0.0002990057,0.000203477,0.0001960407,0.0009648748],"category_scores_gemma":[0.0001330078,0.0001143602,0.0001920701,0.0001383915,0.0001100902,0.0001644575,0.0002083321,0.0003374036,0.0002219397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183468,"about_ca_system_score_gemma":0.000175567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004371033,"about_ca_topic_score_gemma":0.00151749,"domain_scores_codex":[0.9998729,0.00003346508,0.0000101874,0.00001971393,0.00003406018,0.00002962204],"domain_scores_gemma":[0.9999312,0.00001344512,0.00002048336,0.000005155204,0.00001188029,0.00001775105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003244065,0.00008977039,0.0007490318,0.0001494319,0.00001688205,0.00008972006,0.00001674519,0.0002349136,0.9832683,0.0002365428,0.000204547,0.01461965],"study_design_scores_gemma":[0.000247204,0.0056366,0.009149366,0.00003560337,0.00007473387,0.001570004,0.00004440369,0.0020572,0.9627718,0.0001552042,0.01824098,0.00001691267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657198,0.02117786,0.004988501,0.0005157277,0.00007585682,0.0001255455,0.0004457088,0.000134275,0.006816607],"genre_scores_gemma":[0.9900845,0.004112358,0.003710279,0.0001315538,0.00002716572,0.0000262812,0.0002780825,0.000007059808,0.001622696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009648748,"threshold_uncertainty_score":0.00322783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015390460870375,"score_gpt":0.3044995071082773,"score_spread":0.2891090462379023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}