{"id":"W4387871654","doi":"10.1016/j.jcjo.2023.10.008","title":"Surgical technique enhancements for successful subretinal gene therapy delivery","year":2023,"lang":"en","type":"letter","venue":"Canadian Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Genetic enhancement; Medicine; Pars plana; Vitrectomy; Retinal; Ophthalmology; Gene delivery; Retinal detachment; Gene; Visual acuity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005013114,0.0004226755,0.0003065954,0.0007875631,0.001049508,0.0007334366,0.0004266979,0.002677567,0.002373823],"category_scores_gemma":[0.00116901,0.0002527411,0.0008650446,0.0003339817,0.00100563,0.0007662213,0.0004503166,0.00311994,0.0007706592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007301637,"about_ca_system_score_gemma":0.0007808071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001266841,"about_ca_topic_score_gemma":0.005660002,"domain_scores_codex":[0.9997234,0.0000255201,0.00003016072,0.00002539681,0.0001120318,0.00008346399],"domain_scores_gemma":[0.9995062,0.0002386867,0.00005910272,0.00007924755,0.00002709258,0.00008971099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001083028,0.0004061649,0.006821318,0.0004221023,0.0001069751,0.7026075,0.0007720176,0.001312688,0.1090024,0.01003206,0.02700546,0.1404283],"study_design_scores_gemma":[0.0001918708,0.0005530337,0.01319295,0.0000681466,0.00006358162,0.9010834,0.0001817075,0.003547512,0.02078642,0.005701524,0.05456048,0.00006925072],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7145652,0.01901254,0.06827324,0.08192547,0.009046268,0.0005558607,0.0003879956,0.00243899,0.1037944],"genre_scores_gemma":[0.9128662,0.00509551,0.05095177,0.008674667,0.003553462,0.0001778676,0.000133947,0.0002154452,0.0183311],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.002677567,"threshold_uncertainty_score":0.007941186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435925212108637,"score_gpt":0.2758882140615305,"score_spread":0.2515289619404441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}