{"id":"W4387871654","doi":"10.1016/j.jcjo.2023.10.008","title":"Surgical technique enhancements for successful subretinal gene therapy delivery","year":2023,"lang":"en","type":"letter","venue":"Canadian Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Genetic enhancement; Medicine; Pars plana; Vitrectomy; Retinal; Ophthalmology; Gene delivery; Retinal detachment; Gene; Visual acuity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004260842,0.0003320989,0.000460269,0.0003705504,0.0001258982,0.00004164634,0.0006453511,0.001074385,0.0003506843],"category_scores_gemma":[0.00008940916,0.0003158674,0.0003447828,0.000128294,0.0001887368,0.000005491018,0.00003293841,0.0006072233,0.00001484237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006949632,"about_ca_system_score_gemma":0.001866982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221203,"about_ca_topic_score_gemma":0.00005091635,"domain_scores_codex":[0.9981071,0.0001353227,0.0005546616,0.0003606892,0.0001737041,0.0006685248],"domain_scores_gemma":[0.9986278,0.00005935934,0.0004063553,0.0002417763,0.000409098,0.0002555536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000352253,0.00001764356,0.006395716,0.00007839809,0.0003922164,0.04062017,0.00002137083,0.000005211584,0.0052673,0.000004907866,0.9462492,0.000595593],"study_design_scores_gemma":[0.0009549982,0.00142606,0.0005260177,0.00005167519,0.00003282598,0.05033027,0.00001515962,6.750264e-7,0.01387412,0.0002847193,0.932045,0.0004585148],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8854339,0.008656288,0.0007066474,0.08948195,0.004946843,0.001732775,0.0004578433,0.00001337248,0.008570381],"genre_scores_gemma":[0.8413453,0.002400001,0.005797796,0.07538195,0.02156523,0.000686492,0.00704696,0.0007453201,0.04503096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04408861,"threshold_uncertainty_score":0.9999294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435925212108637,"score_gpt":0.2758882140615305,"score_spread":0.2515289619404441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}