{"id":"W4387878168","doi":"10.1101/2023.10.19.563096","title":"GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"GAS6; Insulin receptor; Insulin resistance; Insulin; Endocrinology; Internal medicine; Biology; Endocytosis; MERTK; Cell biology; Receptor; Signal transduction; Receptor tyrosine kinase; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628763,0.0003956508,0.0002068388,0.000265791,0.0001555791,0.0003477837,0.0002387535,0.0004378924,0.003166333],"category_scores_gemma":[0.00006888804,0.0001422033,0.0003475608,0.0001165758,0.0003199427,0.0002672687,0.0002974257,0.0008481886,0.0006989171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003791342,"about_ca_system_score_gemma":0.0001644868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003549657,"about_ca_topic_score_gemma":0.0005062487,"domain_scores_codex":[0.9998338,0.00003140864,0.00001172842,0.00002403228,0.00005484156,0.00004420609],"domain_scores_gemma":[0.9999055,0.00000867062,0.00002729455,0.000008695628,0.000007454787,0.00004231443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005284231,0.00006644659,0.0001904781,0.00007144202,0.0000101925,0.00006434454,0.00001035716,0.00009753808,0.9956949,0.0004069348,0.000347432,0.002511461],"study_design_scores_gemma":[0.0001287835,0.000774508,0.004317874,0.0000149655,0.00002230335,0.0002676712,0.00004746573,0.00133614,0.9850289,0.000202842,0.00785203,0.000006617324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800041,0.005363305,0.00615842,0.001382926,0.0002101103,0.00005796367,0.0009752118,0.0004186513,0.005429378],"genre_scores_gemma":[0.9827215,0.001985332,0.004579144,0.0003383794,0.00005821371,0.00006681073,0.0007012287,0.00006151496,0.009487881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003166333,"threshold_uncertainty_score":0.0105924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01444080500561448,"score_gpt":0.2180257107227541,"score_spread":0.2035849057171396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}