{"id":"W4387880127","doi":"10.1038/s41467-023-42500-2","title":"Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"NHLBI Division of Intramural Research; CIHR Skin Research Training Centre; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; U.S. Military HIV Research Program; Canadian Institutes of Health Research; Mitacs; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; ViiV Healthcare","keywords":"Trimer; Glycoprotein; Crosstalk; Protein structure; Residue (chemistry); Function (biology); Chemistry; Viral envelope; Human immunodeficiency virus (HIV); Viral protein; Plasma protein binding; Biology; Genetics; Virus; Virology; Cell biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009663135,0.0002421899,0.000158679,0.00008765508,0.0001071032,0.0001505156,0.0001625264,0.0002076513,0.000912449],"category_scores_gemma":[0.0001043485,0.00008507559,0.0002305417,0.0001110289,0.0001005652,0.0001165083,0.00006249838,0.0003111989,0.0001571015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307721,"about_ca_system_score_gemma":0.0001527906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001558085,"about_ca_topic_score_gemma":0.001486696,"domain_scores_codex":[0.9999647,0.000006689991,0.000002642424,0.000006185714,0.00000960524,0.00001008966],"domain_scores_gemma":[0.9999732,0.000007379032,0.000007504176,0.000002104198,0.000003153697,0.000006750632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005720338,0.00009829587,0.003992012,0.00003996901,0.00002309122,0.0002401143,0.00003938445,0.002438467,0.9883327,0.0003447589,0.0001045598,0.003774743],"study_design_scores_gemma":[0.0002167839,0.001429093,0.1102247,0.00001913105,0.000113209,0.002352139,0.0001227251,0.06019029,0.8222073,0.0003383696,0.002758906,0.00002721875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991882,0.0001398165,0.0003673915,0.00001638801,0.000001474266,0.000003107053,0.00007786562,0.000007837793,0.0001979447],"genre_scores_gemma":[0.9987898,0.00008422652,0.0006418248,0.00001083507,0.000001452882,0.000002185395,0.0002674924,0.000002633039,0.0001995967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558085,"threshold_uncertainty_score":0.003098011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752429602959975,"score_gpt":0.346032882084744,"score_spread":0.3185085860551443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}