{"id":"W4387890091","doi":"10.1016/s2665-9913(23)00241-2","title":"Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials","year":2023,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; University College London Hospitals Biomedical Research Centre; Genentech; Nordic Pharma Group; Ono Pharmaceutical; National Institute for Health and Care Research; Arthritis Society; British Society for Rheumatology; Argenx; Medical Research Council; Versus Arthritis; Celgene; Biogen; Gilead Sciences; Sanofi; Roche; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Rheumatoid arthritis; Etanercept; Rituximab; Tocilizumab; Internal medicine; Rheumatism; Rheumatology; Population; Clinical trial; Surgery; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002493973,0.0003647473,0.002359871,0.0002272526,0.0001859413,0.00006486496,0.0005317533,0.0002592667,0.0001424961],"category_scores_gemma":[0.0008811075,0.0002023071,0.00007776389,0.0005039054,0.001412277,0.0001394827,0.0001661419,0.0004052715,0.00002721719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002248409,"about_ca_system_score_gemma":0.0001255252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002944144,"about_ca_topic_score_gemma":0.0001512459,"domain_scores_codex":[0.9953437,0.001863506,0.001203123,0.0006034745,0.0002224282,0.0007637121],"domain_scores_gemma":[0.9966128,0.001970657,0.0005659375,0.0005456952,0.0001708337,0.000134058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03917176,0.001248578,0.8611491,0.0001122145,0.0009640217,0.00006098699,0.002157979,0.0000112141,0.032308,0.02128357,0.004472816,0.03705978],"study_design_scores_gemma":[0.4524854,0.009816458,0.4982066,0.001975281,0.00002905921,0.0008532678,0.003701463,0.0004805101,0.002755537,0.02336894,0.004961406,0.001366075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860449,0.007635426,0.00007734093,0.003071386,0.0001005507,0.002551196,0.0002571819,0.0001111923,0.0001508313],"genre_scores_gemma":[0.8617839,0.1365173,0.0005750332,0.0001136802,0.00001243999,0.0004058141,0.0005564057,0.0000238645,0.0000115209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4133136,"threshold_uncertainty_score":0.8249843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0797515025468418,"score_gpt":0.3473685665879094,"score_spread":0.2676170640410676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}