{"id":"W4387890091","doi":"10.1016/s2665-9913(23)00241-2","title":"Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials","year":2023,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; University College London Hospitals Biomedical Research Centre; Genentech; Nordic Pharma Group; Ono Pharmaceutical; National Institute for Health and Care Research; Arthritis Society; British Society for Rheumatology; Argenx; Medical Research Council; Versus Arthritis; Celgene; Biogen; Gilead Sciences; Sanofi; Roche; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Rheumatoid arthritis; Etanercept; Rituximab; Tocilizumab; Internal medicine; Rheumatism; Rheumatology; Population; Clinical trial; Surgery; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01216001,0.002727197,0.004779244,0.0007891486,0.0008357148,0.001607888,0.001425225,0.004304233,0.00399279],"category_scores_gemma":[0.009557188,0.00116268,0.005302124,0.0009925247,0.002353365,0.002264195,0.001259301,0.003236634,0.000734673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001258901,"about_ca_system_score_gemma":0.001906459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162202,"about_ca_topic_score_gemma":0.001367929,"domain_scores_codex":[0.9906914,0.006917528,0.0007434522,0.0008327393,0.0004104284,0.0004044972],"domain_scores_gemma":[0.9933748,0.002431859,0.002072327,0.0006801444,0.0005112047,0.0009296018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9822837,0.003776524,0.0007602158,0.0008870168,0.002193467,0.00002431971,0.00007589557,0.0002230263,0.001433831,0.0001099843,0.0002215538,0.008010561],"study_design_scores_gemma":[0.9372256,0.05991874,0.001185651,0.00006488171,0.0007403296,0.00002940691,0.00001949437,0.0001282253,0.0001772791,0.000183867,0.000310842,0.0000156942],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643827,0.01293035,0.001775933,0.001064825,0.0006672292,0.01633497,0.001344968,0.00008803047,0.001410967],"genre_scores_gemma":[0.9592056,0.004835864,0.005857648,0.002133889,0.0008661125,0.02417345,0.001435878,0.0000301358,0.001461426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01216001,"threshold_uncertainty_score":0.06430912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0797515025468418,"score_gpt":0.3473685665879094,"score_spread":0.2676170640410676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}