{"id":"W4387890110","doi":"10.1016/s2665-9913(23)00238-2","title":"Riociguat in patients with early diffuse cutaneous systemic sclerosis (RISE-SSc): open-label, long-term extension of a phase 2b, randomised, placebo-controlled trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network; Mount Sinai Hospital; Western University","funders":"Merck Sharp and Dohme; Bayer","keywords":"Riociguat; Placebo; Medicine; Adverse effect; Internal medicine; Pulmonary hypertension; Chronic thromboembolic pulmonary hypertension; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002181393,0.002255496,0.005219346,0.0004464358,0.0004164891,0.001361427,0.001089402,0.002638125,0.004810947],"category_scores_gemma":[0.001697865,0.0006334996,0.002683879,0.0004684167,0.001431684,0.001467474,0.0004544036,0.00418817,0.001063336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007250192,"about_ca_system_score_gemma":0.000768695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075335,"about_ca_topic_score_gemma":0.002233913,"domain_scores_codex":[0.9990041,0.0004875291,0.00004569213,0.0001920863,0.00007447353,0.0001961428],"domain_scores_gemma":[0.9991404,0.0003160382,0.0001412951,0.00007483571,0.00006865176,0.0002588337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9741687,0.002931427,0.0004541116,0.0009869662,0.001020445,0.00006293808,0.000057428,0.000187103,0.002481848,0.00009558248,0.000719287,0.01683421],"study_design_scores_gemma":[0.9630647,0.03429944,0.001389276,0.00004220724,0.0004044218,0.00003339285,0.00002188601,0.0001335431,0.0001870299,0.00006875626,0.0003438523,0.00001144809],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665058,0.0238808,0.0009088672,0.001302304,0.001099053,0.002239894,0.0009999346,0.0003191171,0.002744266],"genre_scores_gemma":[0.9830992,0.006613235,0.0015336,0.001793013,0.0006764894,0.002239732,0.001200568,0.00003833311,0.00280594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005219346,"threshold_uncertainty_score":0.01609427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04331733228793644,"score_gpt":0.2998598101575052,"score_spread":0.2565424778695687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}