{"id":"W4387891738","doi":"10.21203/rs.3.rs-3295914/v1","title":"Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Advance Queensland; Medical Research Council; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Cancer Council Victoria; Cancer Australia; National Institute for Health and Care Research; Australian Government; Rosetrees Trust; Pancreatic Cancer UK; Breast Cancer Research Foundation; European Commission; Prostate Cancer Foundation of Australia; Cancer Research Institute; Royal Marsden NHS Foundation Trust; Prostate Cancer Foundation; National Cancer Research Institute; National Institutes of Health; Ovarian Cancer Research Fund; National Health and Medical Research Council; Cancer Research UK","keywords":"Homeobox; Prostate cancer; Androgen receptor; Biology; Cancer; Cancer research; Computational biology; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005379792,0.000251635,0.0004253393,0.0002495164,0.0002248934,0.001079408,0.0002872339,0.0004984763,0.003636611],"category_scores_gemma":[0.0006782186,0.000145243,0.0002269247,0.0002765307,0.0005587427,0.001066882,0.0007555359,0.001231159,0.0006221407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291765,"about_ca_system_score_gemma":0.0005381597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006942463,"about_ca_topic_score_gemma":0.0007123771,"domain_scores_codex":[0.9998348,0.00003316002,0.000004161153,0.00003072685,0.00005653749,0.00004061724],"domain_scores_gemma":[0.999849,0.00005653204,0.00002071449,0.00001424261,0.0000222652,0.00003719013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001896663,0.0001942744,0.02401673,0.002080072,0.0004727466,0.002925268,0.001081927,0.0117672,0.3306914,0.2431763,0.04230147,0.3393959],"study_design_scores_gemma":[0.0001781125,0.0005415,0.07042294,0.0004750331,0.0002933287,0.003435181,0.002177034,0.0444621,0.086328,0.3151269,0.476394,0.0001658281],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6542502,0.225632,0.04184092,0.0315283,0.003470315,0.00003785859,0.0012651,0.0005346012,0.04144081],"genre_scores_gemma":[0.9240624,0.0427268,0.009653928,0.001765435,0.00153178,0.00002656545,0.0007205432,0.0001152851,0.01939728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003636611,"threshold_uncertainty_score":0.01216561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05849800656156946,"score_gpt":0.4067577705350652,"score_spread":0.3482597639734957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}