{"id":"W4387892963","doi":"10.1111/jre.13190","title":"Granzyme B promotes matrix metalloproteinase‐1 (<scp>MMP</scp>‐1) release from gingival fibroblasts in a <scp>PAR1</scp>‐ and Erk1/2‐dependent manner: A novel role in periodontal inflammation","year":2023,"lang":"en","type":"article","venue":"Journal of Periodontal Research","topic":"Oral and gingival health research","field":"Health Professions","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Granzyme B; Granzyme; Matrix metalloproteinase; Chemistry; Matrix metalloproteinase inhibitor; Molecular biology; Immunology; Medicine; Biology; Immune system; Perforin; T cell; Biochemistry; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370184,0.0003952158,0.0002622728,0.0001900957,0.0001067792,0.0003937627,0.0001618474,0.0003662959,0.00217063],"category_scores_gemma":[0.0001713466,0.0001732409,0.0003398844,0.0001359913,0.0002691415,0.000260088,0.0002744248,0.0006800671,0.0006732659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001696652,"about_ca_system_score_gemma":0.0001460119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002050006,"about_ca_topic_score_gemma":0.0002429121,"domain_scores_codex":[0.9998913,0.00001941104,0.00001035151,0.00002763062,0.00002284171,0.0000284122],"domain_scores_gemma":[0.999876,0.00001900201,0.00004548903,0.00001710123,0.00001156513,0.00003074099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003402943,0.00002221805,0.0002093079,0.00005126808,0.000005141572,0.00005841317,0.000008267803,0.00001277566,0.9985654,0.00003059745,0.00004476225,0.0006515373],"study_design_scores_gemma":[0.0001414204,0.0004896701,0.02025214,0.00002285782,0.00002965727,0.001035994,0.0001005404,0.0007621667,0.9747515,0.0002080245,0.002197461,0.000008611231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991016,0.003699878,0.003221837,0.0002720263,0.00004390164,0.00003847662,0.0005622793,0.000124344,0.001021188],"genre_scores_gemma":[0.9942904,0.001406307,0.002008579,0.0000919568,0.00002056802,0.00004656013,0.000351373,0.00002238663,0.001761909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217063,"threshold_uncertainty_score":0.007261455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09215646491973495,"score_gpt":0.4457542282163603,"score_spread":0.3535977632966254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}