{"id":"W4387893443","doi":"10.1158/2159-8290.cd-23-0456","title":"Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Ontario Institute for Cancer Research; Vector Institute; Toronto General Hospital; University Health Network; University of Toronto; Public Health Ontario; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"FDC Foundation; Canadian Institutes of Health Research; Terry Fox Research Institute; Princess Margaret Cancer Foundation","keywords":"Cancer; Li–Fraumeni syndrome; DNA; Computational biology; Cancer research; Genetics; Biology; Medicine; Gene; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001226347,0.0003434619,0.0004697881,0.0006545534,0.000229888,0.0007881517,0.0004609786,0.001586031,0.0007112978],"category_scores_gemma":[0.003331725,0.0002264754,0.0003149702,0.0004077912,0.001180132,0.0005783406,0.0005087209,0.002209766,0.0003912188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004856643,"about_ca_system_score_gemma":0.0002945233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192341,"about_ca_topic_score_gemma":0.003176393,"domain_scores_codex":[0.9993125,0.0002787655,0.00003264241,0.0001200717,0.0001980804,0.00005794651],"domain_scores_gemma":[0.9985415,0.0009598442,0.0001529266,0.00006279381,0.000205265,0.00007772302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003822635,0.0002761361,0.2319912,0.0009997097,0.0003150814,0.007242954,0.0009031534,0.0008943483,0.2027392,0.005198821,0.05673768,0.488879],"study_design_scores_gemma":[0.0005601162,0.003699875,0.2926982,0.001478389,0.000976981,0.04103315,0.001422811,0.0153842,0.4348767,0.0250722,0.1824724,0.000325],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6338652,0.1675742,0.06636772,0.1090961,0.005505042,0.000241713,0.001315713,0.001548631,0.01448567],"genre_scores_gemma":[0.9036133,0.03088129,0.02790939,0.02814007,0.003273485,0.000106779,0.0003523522,0.0001160343,0.005607275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586031,"threshold_uncertainty_score":0.006485641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063909872223783,"score_gpt":0.2414531098952229,"score_spread":0.230814011172985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}