{"id":"W4387893443","doi":"10.1158/2159-8290.cd-23-0456","title":"Early Cancer Detection in Li–Fraumeni Syndrome with Cell-Free DNA","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Ontario Institute for Cancer Research; Vector Institute; Toronto General Hospital; University Health Network; University of Toronto; Public Health Ontario; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"FDC Foundation; Canadian Institutes of Health Research; Terry Fox Research Institute; Princess Margaret Cancer Foundation","keywords":"Cancer; Li–Fraumeni syndrome; DNA; Computational biology; Cancer research; Genetics; Biology; Medicine; Gene; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098665,0.0002559643,0.0003740737,0.0003329412,0.00006343227,0.00005258805,0.0001671676,0.0001616669,0.0001304248],"category_scores_gemma":[0.00002263792,0.0002276093,0.0001044299,0.001316889,0.00008661981,0.000320972,0.00009140824,0.0004208511,0.00008381886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008910849,"about_ca_system_score_gemma":0.0005657477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004121326,"about_ca_topic_score_gemma":0.004641236,"domain_scores_codex":[0.9982125,0.00003236076,0.0002662399,0.0005311701,0.0004364162,0.0005213023],"domain_scores_gemma":[0.9990445,0.00002821407,0.0001019746,0.000621742,0.00005658891,0.0001469609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005282515,0.0006410623,0.1099969,0.002164589,0.001069832,0.009316662,0.004135847,0.01743555,0.7882756,0.0001254794,0.01754772,0.04400827],"study_design_scores_gemma":[0.01627317,0.001874942,0.6239703,0.00319058,0.0006462218,0.0003427091,0.0006218497,0.001115334,0.339251,0.0002953085,0.01106349,0.001355102],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937605,0.002020991,0.0002783855,0.0007205053,0.0008118823,0.000629538,0.0001000056,0.0002036396,0.001474545],"genre_scores_gemma":[0.9933017,0.001070755,0.00002148385,0.0003062316,0.0002005935,0.0006387968,0.00002309613,0.00009658506,0.004340702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5139734,"threshold_uncertainty_score":0.9281638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063909872223783,"score_gpt":0.2414531098952229,"score_spread":0.230814011172985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}