{"id":"W4387893954","doi":"10.1007/s00011-023-01805-0","title":"Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation","year":2023,"lang":"en","type":"article","venue":"Inflammation Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières; Centre Hospitalier de l’Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Epigenetics; Methylation; DNA methylation; Lipoxygenase; Epigenomics; Arachidonate 5-lipoxygenase; Biology; Cell biology; Gene expression; Genetics; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479717,0.0001073725,0.000174796,0.000193943,0.0001575199,0.0002672442,0.0001263549,0.0001263182,0.00187124],"category_scores_gemma":[0.0002539331,0.0001256859,0.0002578402,0.000177827,0.0001482959,0.00009564028,0.0001852203,0.0001972852,0.0002719098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632572,"about_ca_system_score_gemma":0.0002033263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002648966,"about_ca_topic_score_gemma":0.005312137,"domain_scores_codex":[0.9998611,0.00002091589,0.000009018189,0.00004605911,0.00002939513,0.00003343711],"domain_scores_gemma":[0.9999197,0.00001904138,0.00002541057,0.000009916504,0.0000174725,0.000008528829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005086617,0.00002025496,0.01371309,0.00009967817,0.00005349991,0.0001265087,0.0003667114,0.0001148904,0.9733452,0.0003823094,0.0001457134,0.01112348],"study_design_scores_gemma":[0.00009428192,0.0005201124,0.4200388,0.00006827236,0.000245515,0.0008874643,0.0007681931,0.002041609,0.5643679,0.000451082,0.01048368,0.00003299431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894735,0.00479451,0.003081989,0.0001147707,0.00004857748,0.00001646242,0.0005559096,0.00003518963,0.00187902],"genre_scores_gemma":[0.996534,0.0006962366,0.0005332899,0.00003812663,0.000008984915,0.0000122319,0.0002579399,0.000008348786,0.001910808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002648966,"threshold_uncertainty_score":0.006259859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005455479512164,"score_gpt":0.379197420486263,"score_spread":0.3291428656911414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}