{"id":"W4387895479","doi":"10.1101/2023.10.23.563477","title":"ENDOTHELIAL GENE REGULATORY ELEMENTS ASSOCIATED WITH CARDIOPHARYNGEAL LINEAGE DIFFERENTIATION","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Fondation Leducq","keywords":"Enhancer; Mesoderm; Biology; Transcription factor; FGF and mesoderm formation; Genetics; Computational biology; Chromatin; Lateral plate mesoderm; Cis-regulatory module; Gene; Cellular differentiation; Cell biology; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792827,0.0001947457,0.0001814133,0.0002234059,0.0001144206,0.0002507441,0.0001683265,0.0001961679,0.001522404],"category_scores_gemma":[0.0004644773,0.0001616099,0.0002557566,0.0002565868,0.0001343483,0.0001378957,0.0001522527,0.0003015438,0.0002356179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002272,"about_ca_system_score_gemma":0.0002716967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001535855,"about_ca_topic_score_gemma":0.001769795,"domain_scores_codex":[0.9999073,0.00001360983,0.000004653387,0.00004117845,0.00002262322,0.00001065276],"domain_scores_gemma":[0.9998496,0.00007535529,0.00002683068,0.00001455408,0.00002173113,0.00001201577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004749368,0.0001939886,0.09857324,0.0004976376,0.0001238092,0.0002948318,0.0001026434,0.2446167,0.5961317,0.004326977,0.001546862,0.05311677],"study_design_scores_gemma":[0.00003479263,0.00009805289,0.07389013,0.00002280369,0.00004988527,0.0001783287,0.00003809151,0.7613651,0.1587416,0.003103063,0.00246017,0.00001795224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938724,0.0002969324,0.0558795,0.00006120054,0.00001342084,0.00001905048,0.002824182,0.0005104554,0.001671199],"genre_scores_gemma":[0.9800633,0.0001173897,0.01591039,0.00001760345,0.000003972967,0.00001958751,0.003253374,0.00005236223,0.0005619515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535855,"threshold_uncertainty_score":0.005092919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663949407223307,"score_gpt":0.2410988911762826,"score_spread":0.2244593971040495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}