{"id":"W4387902659","doi":"10.1101/2023.10.23.23297381","title":"Genetic analysis of selection bias in a natural experiment: Investigating in-utero famine effects on elevated body mass index in the Dutch Hunger Winter Families Study","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canadian Institute for Advanced Research","keywords":"Famine; Demography; In utero; Body mass index; Natural experiment; Natural selection; Offspring; Obesity; Ice calving; Medicine; Biology; Population; Pregnancy; Fetus; Genetics; Endocrinology; Geography; Lactation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02245741,0.0004953027,0.0006525077,0.0004587533,0.000942294,0.0006840061,0.0007155798,0.0006035301,0.0009487099],"category_scores_gemma":[0.02931187,0.0003339521,0.00100165,0.0006198177,0.001406795,0.0003816512,0.0006918806,0.0005078553,0.00008663676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007671673,"about_ca_system_score_gemma":0.001105013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01820479,"about_ca_topic_score_gemma":0.02222848,"domain_scores_codex":[0.9701198,0.02637999,0.000603307,0.001641113,0.0008625186,0.0003932133],"domain_scores_gemma":[0.9750262,0.01456205,0.003653276,0.005311478,0.0008146317,0.0006322291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003275836,0.0007692143,0.9693963,0.0001160109,0.003952934,0.0006249158,0.002250723,0.000805689,0.008918857,0.00150512,0.0004352588,0.007949335],"study_design_scores_gemma":[0.0003785797,0.00188319,0.9890339,0.00002543088,0.0008029657,0.0003069298,0.0004875691,0.002810404,0.001765201,0.001103138,0.001360736,0.00004204183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941506,0.0002291963,0.004891861,0.00007408833,0.00001999865,0.0001004186,0.0002407881,0.000009138977,0.0002837824],"genre_scores_gemma":[0.9963017,0.00006737154,0.002942434,0.00009580131,0.00001113723,0.0001857286,0.0002019906,0.000008855472,0.000185049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02245741,"threshold_uncertainty_score":0.1187676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05147070067790292,"score_gpt":0.3356510237619557,"score_spread":0.2841803230840528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}