{"id":"W4387933875","doi":"10.1016/j.jcjd.2023.10.369","title":"THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"AMPK; Medicine; Metformin; Dyslipidemia; Inflammation; Activator (genetics); Disease; Bioavailability; Pharmacology; Canagliflozin; Diabetes mellitus; Kinase; Internal medicine; Endocrinology; Protein kinase A; Type 2 diabetes; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003751615,0.0008661452,0.001055318,0.0008309956,0.000466976,0.0006285806,0.0007017312,0.0009788456,0.003929296],"category_scores_gemma":[0.0002010521,0.0005555737,0.0007938971,0.0004579127,0.0006670817,0.0005310774,0.0003499178,0.003058507,0.001124414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005135596,"about_ca_system_score_gemma":0.0009639857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001484876,"about_ca_topic_score_gemma":0.003121924,"domain_scores_codex":[0.9995887,0.00003383737,0.00002842661,0.00007326967,0.00009362079,0.0001820824],"domain_scores_gemma":[0.9998302,0.00001230811,0.00004541859,0.00001686084,0.00001660233,0.00007852045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01057059,0.001502655,0.0004015144,0.0004737147,0.0001264219,0.0002251049,0.00007662008,0.0004877028,0.966428,0.001036309,0.002018577,0.01665278],"study_design_scores_gemma":[0.002429418,0.006424483,0.00421305,0.00008724403,0.0002966097,0.0003867727,0.0002006091,0.001434884,0.9720737,0.0006444789,0.01176731,0.00004147177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721454,0.007449987,0.004813462,0.002591168,0.0009267402,0.0001508292,0.002090903,0.0009186307,0.00891276],"genre_scores_gemma":[0.9761695,0.006481382,0.004089065,0.0009163736,0.0001952496,0.0003137798,0.001315629,0.0001483495,0.01037061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003929296,"threshold_uncertainty_score":0.01314479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298159138590787,"score_gpt":0.2476690931186374,"score_spread":0.2346875017327295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}