{"id":"W4387934236","doi":"10.1016/j.jcjd.2023.10.032","title":"THE ROLE OF MICRORNAS IN HYPERTROPHIC CARDIOMYOPATHY: INSIGHTS FROM PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELL CARDIOMYOCYTES AND MYOCARDIAL TISSUE","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Hypertrophic cardiomyopathy; Induced pluripotent stem cell; MYH7; Medicine; microRNA; Myosin; Myocyte; Muscle hypertrophy; Disease; MYH6; Cardiology; Bioinformatics; Internal medicine; Cell biology; Gene; Myosin light-chain kinase; Genetics; Biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006234079,0.0002383973,0.000294882,0.000430491,0.0002271637,0.0008042465,0.0002552275,0.0005220782,0.001072244],"category_scores_gemma":[0.0004686532,0.0002002875,0.0002489141,0.0002024352,0.000400962,0.0003612204,0.0004042884,0.000720666,0.0002040037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939661,"about_ca_system_score_gemma":0.0004805159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005569811,"about_ca_topic_score_gemma":0.001296602,"domain_scores_codex":[0.999756,0.00005709871,0.00002840373,0.0000388822,0.0000862618,0.00003332721],"domain_scores_gemma":[0.9998411,0.00005653148,0.00003272165,0.00001404233,0.00003222351,0.0000233442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004664586,0.00007653752,0.01218013,0.0003987938,0.00006964011,0.002845046,0.0005060737,0.0003060715,0.9327218,0.007835926,0.0009575867,0.04163601],"study_design_scores_gemma":[0.0001229646,0.001548062,0.184733,0.0002819681,0.0004033664,0.01691209,0.002028069,0.003424779,0.7171382,0.005144532,0.06817875,0.0000843348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9016582,0.05891766,0.01914766,0.003277603,0.0004638245,0.000113643,0.000910503,0.0001497235,0.01536113],"genre_scores_gemma":[0.9748472,0.0154775,0.005376746,0.0009507607,0.0001262846,0.00005370069,0.0004523816,0.00003140421,0.002683981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072244,"threshold_uncertainty_score":0.003587067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00896869602723128,"score_gpt":0.1942412723855294,"score_spread":0.1852725763582981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}