{"id":"W4387934645","doi":"10.1073/pnas.2304302120","title":"Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Medizinische Universität Graz; Hospital for Sick Children; Karl-Franzens-Universität Graz; Canada Foundation for Innovation; University of Wisconsin-Madison","keywords":"Folding (DSP implementation); Computational biology; Intrinsically disordered proteins; Conditional independence; Protein folding; Protein structure; Function (biology); Structure function; Computer science; Biology; Genetics; Physics; Biophysics; Artificial intelligence; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006926233,0.0000632686,0.0001277908,0.0000822591,0.00008733767,0.00001132104,0.0005144981,0.00008121321,0.000001486232],"category_scores_gemma":[0.0007836242,0.00004475679,0.00007373875,0.0004982995,0.000433716,0.00001737954,0.000106169,0.0000467343,7.512521e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006718274,"about_ca_system_score_gemma":0.00003008096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001399634,"about_ca_topic_score_gemma":6.475776e-8,"domain_scores_codex":[0.9987861,0.000008132502,0.0003891418,0.0001682399,0.0005630638,0.00008533894],"domain_scores_gemma":[0.9991099,0.00004031948,0.0005333936,0.0000136326,0.0002846693,0.00001804596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007044285,0.00001661482,0.0003042247,0.000491179,0.00002561807,1.155755e-9,0.00002571696,0.00004300926,0.9567046,0.04048016,0.001884538,0.00001730466],"study_design_scores_gemma":[0.0001812157,0.00005397131,0.01146873,0.0002501773,0.0000238945,0.000004203604,0.0001236018,0.0006579457,0.9014168,0.08568472,0.0000556801,0.00007909509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971368,0.0002031958,0.00005759512,0.001546524,0.00001960966,0.0003346814,0.00009534668,0.000008084636,0.0005982136],"genre_scores_gemma":[0.9993439,0.00005369391,0.0002049876,0.00007547111,0.0000252449,0.00002272102,0.00000654384,0.000003270261,0.0002642191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05528783,"threshold_uncertainty_score":0.1825129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456830728957386,"score_gpt":0.2815389808437856,"score_spread":0.2669706735542118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}