{"id":"W4387938980","doi":"10.3389/fphar.2023.1145413","title":"Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Guelph; Saint John Regional Hospital","funders":"Science and Technology Planning Project of Guangdong Province; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Polyunsaturated fatty acid; Receptor; PI3K/AKT/mTOR pathway; Apelin; Biology; Internal medicine; Endocrinology; Signal transduction; Agonist; Protein kinase B; Pharmacology; Cell biology; Biochemistry; Medicine; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003215852,0.0004109408,0.0005464441,0.0003386989,0.0002307294,0.0003669576,0.0003681224,0.0004620932,0.002511172],"category_scores_gemma":[0.0001434627,0.0002062499,0.0006005186,0.000180568,0.00036009,0.000337658,0.000267882,0.001378308,0.0006670941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302576,"about_ca_system_score_gemma":0.0002186098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003117473,"about_ca_topic_score_gemma":0.0005653602,"domain_scores_codex":[0.9997098,0.00002106955,0.00002431496,0.0001069791,0.00006442299,0.00007341433],"domain_scores_gemma":[0.9998419,0.00001844427,0.00004936023,0.00001911473,0.00001946883,0.00005175577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006305823,0.00005047777,0.0001320643,0.0001136394,0.00001484141,0.00004656807,0.0000223455,0.00005844639,0.9975252,0.00005361031,0.00008286857,0.001269436],"study_design_scores_gemma":[0.0001309132,0.001203489,0.007112039,0.00003895003,0.0001149039,0.0001915309,0.0001052281,0.001226616,0.9856985,0.000127768,0.004034249,0.00001580781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840709,0.004698499,0.006335417,0.0003170285,0.000187019,0.00007652542,0.002016518,0.0002786267,0.002019535],"genre_scores_gemma":[0.9763664,0.004213367,0.008143105,0.0004418265,0.00006068979,0.0005138699,0.002707586,0.0001342661,0.007419039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002511172,"threshold_uncertainty_score":0.008400738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547763501691663,"score_gpt":0.3086477350442567,"score_spread":0.2831701000273401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}