{"id":"W4387938980","doi":"10.3389/fphar.2023.1145413","title":"Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Guelph; Saint John Regional Hospital","funders":"Science and Technology Planning Project of Guangdong Province; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Polyunsaturated fatty acid; Receptor; PI3K/AKT/mTOR pathway; Apelin; Biology; Internal medicine; Endocrinology; Signal transduction; Agonist; Protein kinase B; Pharmacology; Cell biology; Biochemistry; Medicine; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009117274,0.0003020045,0.0006216009,0.001051344,0.00007891873,0.00001433622,0.0001600988,0.0007144769,0.0009048578],"category_scores_gemma":[0.0005610311,0.0002884667,0.00008892897,0.002731913,0.0003765682,0.0001140212,0.0001349686,0.00177646,0.0004222675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000704732,"about_ca_system_score_gemma":0.0004116129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172482,"about_ca_topic_score_gemma":0.000006682641,"domain_scores_codex":[0.9965007,0.0004265498,0.0006946786,0.0006828224,0.0005834937,0.001111781],"domain_scores_gemma":[0.9989704,0.0001406137,0.0001027319,0.0002421982,0.0001392761,0.000404798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001572402,0.0003590088,0.00277979,0.00007093872,0.00006867258,0.0006697424,0.000278685,0.00000955718,0.7575886,5.262248e-7,0.2328028,0.003799211],"study_design_scores_gemma":[0.01209075,0.000487654,0.001403154,0.000104649,0.00004652377,0.00006144744,0.0003196652,0.005320195,0.9503865,0.00003385643,0.02941045,0.0003351595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881611,0.0006970242,0.0002465598,0.006876738,0.00111073,0.00217854,0.0000644238,0.0003646935,0.0003001193],"genre_scores_gemma":[0.9900171,0.00121074,0.002052837,0.001768743,0.0002815308,0.0005506439,0.001117438,0.0001005005,0.002900534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2033924,"threshold_uncertainty_score":0.9999567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547763501691663,"score_gpt":0.3086477350442567,"score_spread":0.2831701000273401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}