{"id":"W4387939747","doi":"10.37349/etat.2023.00175","title":"Biomarkers in renal cell carcinoma and their targeted therapies: a review","year":2023,"lang":"en","type":"review","venue":"Exploration of Targeted Anti-tumor Therapy","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Renal cell carcinoma; Targeted therapy; Immunotherapy; Cancer; Biomarker; Kidney cancer; Sunitinib; microRNA; Epigenetics; Bioinformatics; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008452815,0.001031928,0.003978333,0.0009827267,0.00008359049,0.00003416572,0.0002951022,0.0002922289,0.0001581274],"category_scores_gemma":[0.00007492061,0.0006975709,0.0008758084,0.001703925,0.0001736723,0.0002901634,0.00006948232,0.0005169666,0.00006546189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160685,"about_ca_system_score_gemma":0.0005769027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007082115,"about_ca_topic_score_gemma":0.000007532884,"domain_scores_codex":[0.9954755,0.0006865524,0.001852968,0.0009564883,0.0004963239,0.0005321644],"domain_scores_gemma":[0.9972105,0.0002723807,0.001160618,0.000921292,0.0002120876,0.0002230963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000627267,0.001616598,0.000379476,0.1897319,0.003725128,0.001170854,0.003054022,0.0000034716,0.006915061,0.00005923205,0.007102916,0.7856141],"study_design_scores_gemma":[0.005716505,0.002387287,0.0006932556,0.09551216,0.001174064,0.0001955931,0.0006849162,0.00004700814,0.006901179,0.000157364,0.8849364,0.001594248],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003668781,0.9906436,0.00002578338,0.0003120393,0.0002092327,0.004709743,0.0001445986,0.0001377852,0.0001485046],"genre_scores_gemma":[0.003741316,0.9931084,0.0002934363,0.0002397562,0.0001396689,0.0007210689,0.001348451,0.0002346152,0.0001732789],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8778335,"threshold_uncertainty_score":0.9995475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09424957999287563,"score_gpt":0.32209218553763,"score_spread":0.2278426055447544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}