{"id":"W4387941019","doi":"10.1016/j.jphotochem.2023.115273","title":"Donor-acceptor functionalized coumarin derivatives: Synthesis, fluorescence modulation, interaction with human serum albumin and acetylcholinesterase inhibition activity","year":2023,"lang":"en","type":"article","venue":"Journal of Photochemistry and Photobiology A Chemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Science and Engineering Research Board; Ministry of Rural Affairs; Department of Science and Technology, Ministry of Science and Technology, India; North-Eastern Hill University","keywords":"Chemistry; Fluorescence; Human serum albumin; Rational design; Photochemistry; Acetylcholinesterase; Bovine serum albumin; Excited state; Chromophore; Acceptor; Combinatorial chemistry; Organic chemistry; Enzyme; Biochemistry; Materials science; Nanotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141116,0.0002058303,0.0001163519,0.0001017474,0.00009429675,0.0001224259,0.0001801681,0.0002243883,0.0007300242],"category_scores_gemma":[0.0001373707,0.0000701598,0.0001178255,0.0001467687,0.0001268539,0.0001376321,0.0000745644,0.0002671719,0.0001757005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002856157,"about_ca_system_score_gemma":0.0001173141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006426941,"about_ca_topic_score_gemma":0.000796138,"domain_scores_codex":[0.9999461,0.000009977945,0.000003543618,0.00001183578,0.00001101457,0.00001752651],"domain_scores_gemma":[0.9999404,0.00001236939,0.00001950379,0.000007543644,0.000009069908,0.00001106914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007698603,0.00001981809,0.00007178146,0.00001893752,0.000002216011,0.00005357312,0.00001615236,0.0001495666,0.9982288,0.0001479702,0.00002299456,0.001191111],"study_design_scores_gemma":[0.000002593785,0.00007545792,0.000427423,6.575715e-7,0.000002895902,0.00003520828,0.00000362312,0.0002220456,0.998708,0.00001092764,0.0005093803,0.000001812656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935163,0.0007296587,0.004282361,0.00006961838,0.000009574504,0.00001344609,0.0001201838,0.00005357246,0.001205346],"genre_scores_gemma":[0.9960288,0.0003258914,0.001864734,0.00002338668,0.000002594006,0.000007591754,0.00009553351,0.000009217483,0.001642403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007300242,"threshold_uncertainty_score":0.002442241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127791155610054,"score_gpt":0.271800593992177,"score_spread":0.2590214784311716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}