{"id":"W4387946694","doi":"10.1093/neuonc/noad208","title":"Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Deutsche Forschungsgemeinschaft","keywords":"Proteome; Tumor microenvironment; Metabolome; Lipidomics; Immune system; Omics; Proteomics; Tumor progression; Metabolomics; Reprogramming; Cancer research; Computational biology; Basigin; Cell; Biology; Bioinformatics; Cancer; Immunology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155804,0.0002467904,0.000233129,0.0009446735,0.0001608932,0.00034274,0.0001064834,0.0001868859,0.0009591884],"category_scores_gemma":[0.0002262052,0.00007697826,0.0002194812,0.0004716372,0.0001730582,0.0001463908,0.000306758,0.0001987288,0.0002423996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067646,"about_ca_system_score_gemma":0.0001281557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007075995,"about_ca_topic_score_gemma":0.0007153337,"domain_scores_codex":[0.9999111,0.000006876826,0.00001063944,0.00002408397,0.00002342079,0.00002401059],"domain_scores_gemma":[0.9998707,0.00001144602,0.0000509103,0.00001253233,0.00002216084,0.00003231155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001113568,0.00004428386,0.148908,0.0001007915,0.00006933384,0.0006731095,0.0001751379,0.00008006164,0.8374338,0.00007430949,0.0001855983,0.01114204],"study_design_scores_gemma":[0.000009977941,0.000372815,0.9227028,0.000008775632,0.0000647956,0.002761683,0.0002212841,0.000491538,0.07219849,0.0001173532,0.00104274,0.000007688158],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983367,0.0003048486,0.0004079789,0.00002126319,0.000003654546,0.000009976573,0.000616141,0.00002203186,0.0002774133],"genre_scores_gemma":[0.9973386,0.0002115182,0.0008015108,0.00002980839,0.000006727115,0.00002019291,0.001378523,0.00000933377,0.0002038171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009591884,"threshold_uncertainty_score":0.003208816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131400021762956,"score_gpt":0.2692886709685247,"score_spread":0.2579746707508951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}