{"id":"W4387946694","doi":"10.1093/neuonc/noad208","title":"Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Deutsche Forschungsgemeinschaft","keywords":"Proteome; Tumor microenvironment; Metabolome; Lipidomics; Immune system; Omics; Proteomics; Tumor progression; Metabolomics; Reprogramming; Cancer research; Computational biology; Basigin; Cell; Biology; Bioinformatics; Cancer; Immunology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004260118,0.0003991231,0.000952613,0.0004259175,0.0001858131,0.00001464221,0.0004669473,0.0007033215,0.0002868051],"category_scores_gemma":[0.0001020199,0.0002996059,0.0001009495,0.0005774772,0.000685254,0.0001709281,0.0002945975,0.0009576851,0.0001282508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006091062,"about_ca_system_score_gemma":0.0003702574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007133227,"about_ca_topic_score_gemma":0.00005063411,"domain_scores_codex":[0.9970009,0.0009558806,0.0006295174,0.0006708517,0.00009036563,0.0006525408],"domain_scores_gemma":[0.9981614,0.0004845685,0.0004837796,0.0006073583,0.0001931233,0.00006978707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004971797,0.0003525174,0.00004004432,0.00006895696,0.0001308525,0.00005743375,0.0008471088,0.0000138178,0.9817605,0.0002727818,0.001827236,0.009656965],"study_design_scores_gemma":[0.004751638,0.00414766,0.001837293,0.00002164432,0.0001511719,0.0001755835,0.0001530794,0.0000147973,0.7512449,0.00004872378,0.2371725,0.0002809947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900158,0.003379033,0.00001836804,0.0004771239,0.003892031,0.000972507,0.0001198737,0.0002156531,0.0009096191],"genre_scores_gemma":[0.9973719,0.001022791,0.0003515228,0.0003389859,0.0002623684,0.0001768501,0.0001940133,0.00007923175,0.000202408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2353453,"threshold_uncertainty_score":0.9999456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131400021762956,"score_gpt":0.2692886709685247,"score_spread":0.2579746707508951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}