{"id":"W4387948630","doi":"10.1021/acsinfecdis.3c00289","title":"Confronting the Threat: Designing Highly Effective bis-Benzimidazolium Agents to Overcome Biofilm Persistence and Antimicrobial Resistance","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Collège de Bois-de-Boulogne; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biofilm; Persistence (discontinuity); Antimicrobial; Microbiology; Antibiotic resistance; Anti-Infective Agents; Resistance (ecology); Chemistry; Biology; Antibiotics; Bacteria; Ecology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228496,0.000472578,0.0004173585,0.0003328349,0.000195587,0.0005386606,0.0005297558,0.000551221,0.0006369414],"category_scores_gemma":[0.0003015817,0.0001957014,0.0001843782,0.0001739222,0.0001722265,0.0005783229,0.0003454343,0.0006923873,0.0003280118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354292,"about_ca_system_score_gemma":0.0004427575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00060875,"about_ca_topic_score_gemma":0.001943476,"domain_scores_codex":[0.9998738,0.00002737674,0.00001132933,0.00001657115,0.00003496143,0.00003602347],"domain_scores_gemma":[0.9999,0.00001575295,0.0000286375,0.00000581246,0.00002407145,0.00002569934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000948435,0.0001566064,0.0002075137,0.0003944192,0.00001794229,0.0001394157,0.00005270727,0.001562397,0.9752642,0.00123843,0.000237768,0.02063384],"study_design_scores_gemma":[0.0001510461,0.002105305,0.001187068,0.0001197731,0.0000894179,0.0003990088,0.00009445682,0.007986721,0.9619086,0.0005615856,0.02535869,0.00003824993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8969003,0.04405735,0.04693549,0.002190783,0.000283766,0.0006790899,0.0002127942,0.0003838486,0.008356585],"genre_scores_gemma":[0.9449882,0.01969785,0.03065561,0.0005728071,0.0000663185,0.0002629474,0.0001565348,0.00003156884,0.003568071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006369414,"threshold_uncertainty_score":0.00257057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133955026601239,"score_gpt":0.2391638331984853,"score_spread":0.2278242829324729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}