{"id":"W4387948630","doi":"10.1021/acsinfecdis.3c00289","title":"Confronting the Threat: Designing Highly Effective bis-Benzimidazolium Agents to Overcome Biofilm Persistence and Antimicrobial Resistance","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Collège de Bois-de-Boulogne; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biofilm; Persistence (discontinuity); Antimicrobial; Microbiology; Antibiotic resistance; Anti-Infective Agents; Resistance (ecology); Chemistry; Biology; Antibiotics; Bacteria; Ecology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147167,0.0002124338,0.0001785548,0.00006876849,0.000472542,0.0001412796,0.0001333151,0.00009956344,0.000004398878],"category_scores_gemma":[0.0002197268,0.0001734493,0.00008847428,0.0002615877,0.0001301606,0.00001226825,0.0002176623,0.00007925375,0.0000201318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002447,"about_ca_system_score_gemma":0.00004520685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009940644,"about_ca_topic_score_gemma":0.00009368554,"domain_scores_codex":[0.9987951,0.000104979,0.0001603033,0.0004543606,0.0001062976,0.0003789792],"domain_scores_gemma":[0.9993532,0.00007116261,0.00007811854,0.0002938476,0.00007754714,0.0001261236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074571,0.00002835943,0.0206827,0.0000420694,0.00008295108,0.00001168183,0.0001401268,0.00005068983,0.9711853,0.00005016217,0.006293262,0.001325219],"study_design_scores_gemma":[0.001358203,0.0004447671,0.4302023,0.0002410167,0.0002332053,0.00004306199,0.0004076605,0.00003497929,0.5513339,0.00006034829,0.01474046,0.0009001087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976034,0.0004396259,0.00004620892,0.0003327358,0.000410302,0.0004227341,0.00009444358,0.00009218414,0.0005584114],"genre_scores_gemma":[0.9983742,0.0001836688,0.00005270973,0.0006058114,0.0003169794,0.00002771994,0.00007507144,0.00003109332,0.0003327718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4198514,"threshold_uncertainty_score":0.7073058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133955026601239,"score_gpt":0.2391638331984853,"score_spread":0.2278242829324729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}