{"id":"W4387950505","doi":"10.1261/rna.079030.121","title":"miR-7 is recruited to the high molecular weight RNA-induced silencing complex in CD8<sup>+</sup>T cells upon activation and suppresses IL-2 signaling","year":2023,"lang":"en","type":"article","venue":"RNA","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Environment Research Council; Biotechnology and Biological Sciences Research Council; University of Edinburgh; Medical Research Council Canada; International Seafood Sustainability Foundation; Wellcome Trust; Medical Research Council; Directorate for Biological Sciences; Wellcome","keywords":"Biology; Gene silencing; Cell biology; RNA silencing; RNA; CD8; RNA-induced silencing complex; Cytotoxic T cell; RNA interference; Molecular biology; Genetics; Immune system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008554629,0.0001447344,0.0002422785,0.0001839687,0.0001643915,0.0004422663,0.0001599095,0.000221309,0.001346837],"category_scores_gemma":[0.0001299536,0.000129843,0.0001744344,0.0001114523,0.000202562,0.0001124319,0.0002058727,0.0004905098,0.0008282859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561434,"about_ca_system_score_gemma":0.0001479188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002287541,"about_ca_topic_score_gemma":0.0004819124,"domain_scores_codex":[0.9998503,0.00002084501,0.00001325457,0.00002944702,0.0000452265,0.00004102867],"domain_scores_gemma":[0.999895,0.00001537928,0.00002751594,0.00001190136,0.00001415997,0.00003600002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009180819,0.000009198122,0.0002051024,0.00001210996,0.000002450678,0.00004093619,0.000009009304,0.00002293084,0.9990979,0.00004346508,0.00002957911,0.0004354617],"study_design_scores_gemma":[0.00002012851,0.0001426983,0.01291729,0.000005216856,0.00001026414,0.0003064545,0.00004584338,0.001537151,0.983144,0.00006289341,0.001804407,0.000003660805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958993,0.0008305849,0.001518258,0.0000727048,0.00002116845,0.00001189999,0.0002014805,0.00006989473,0.001374619],"genre_scores_gemma":[0.9957455,0.0001989479,0.001521536,0.00006607448,0.00001289575,0.00002647415,0.0005934772,0.00003177774,0.001803316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346837,"threshold_uncertainty_score":0.004505575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301762353208277,"score_gpt":0.2603734534182059,"score_spread":0.2373558298861232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}