{"id":"W4387950545","doi":"10.1038/s41467-023-42526-6","title":"Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; Vetenskapsrådet; Austrian Science Fund; National Institute of Allergy and Infectious Diseases; Karolinska Institutet; Innovative Medicines Initiative; Bundesministerium für Bildung und Forschung; Österreichischen Akademie der Wissenschaften; Vienna Science and Technology Fund","keywords":"Ebola virus; Marburg virus; Virology; Filoviridae; Endosome; Biology; Ebolavirus; Lassa virus; Viral entry; Virus; Viral replication; Receptor; Genetics; Viral disease; Paramyxoviridae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080543,0.0002496349,0.00021683,0.0002724698,0.0001772715,0.0002580468,0.0001505226,0.0002778156,0.0006331858],"category_scores_gemma":[0.0001306701,0.0000842525,0.000180341,0.0001452501,0.0001843835,0.0001496912,0.0002162719,0.0002501286,0.0001980546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004352786,"about_ca_system_score_gemma":0.0002820505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009043503,"about_ca_topic_score_gemma":0.0009102057,"domain_scores_codex":[0.9999427,0.000008452247,0.000004271781,0.00001317871,0.00001712801,0.00001429372],"domain_scores_gemma":[0.9999365,0.00001214586,0.0000183714,0.000006635235,0.000007262175,0.00001908439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001043671,0.00000757414,0.0006208034,0.00002328516,0.000002452415,0.00008152059,0.000008439401,0.0001430476,0.9977317,0.0001238924,0.00002960194,0.001123314],"study_design_scores_gemma":[0.00001524757,0.0000995501,0.01169603,0.000005937147,0.00001281161,0.0004691611,0.00002504438,0.001812467,0.9829457,0.00007293674,0.002838508,0.000006635201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938451,0.002927682,0.00190354,0.0001164776,0.00001182698,0.00002278352,0.0004056442,0.00005341813,0.000713439],"genre_scores_gemma":[0.9962885,0.0008684434,0.001548692,0.00003865017,0.000003701145,0.00001616934,0.0005819484,0.00001095288,0.0006428896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009043503,"threshold_uncertainty_score":0.003158152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411045651552839,"score_gpt":0.3800209632100759,"score_spread":0.3559105066945475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}