{"id":"W4387952652","doi":"10.1101/2023.10.25.563967","title":"Discovery of a novel inhibitor of macropinocytosis with antiviral activity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Vetenskapsrådet; Karolinska Institutet; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden; European Federation of Pharmaceutical Industries and Associations; McGill University","keywords":"Pinocytosis; Endocytosis; Viral entry; Endocytic cycle; Virology; Virus; Biology; Monkeypox; Limiting; Cell biology; Cell; Viral replication; Biochemistry; Recombinant DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487183,0.0003421719,0.0003357292,0.0002729305,0.0001523219,0.0003223166,0.0003563199,0.0002895747,0.001886063],"category_scores_gemma":[0.0000804147,0.0001323786,0.0002551424,0.0001207866,0.0001602916,0.0001558193,0.0002257962,0.0006925866,0.000586549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479559,"about_ca_system_score_gemma":0.0002676366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273961,"about_ca_topic_score_gemma":0.0003780203,"domain_scores_codex":[0.9999599,0.000004920951,0.000003318463,0.000009112724,0.00001155118,0.00001116394],"domain_scores_gemma":[0.999963,0.000007190448,0.000006163715,0.000003449725,0.000006447529,0.00001372343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000311105,0.0001740866,0.0003333159,0.0002758286,0.0000362327,0.0002383915,0.00003597341,0.0005368455,0.9707386,0.001132571,0.000892414,0.02529464],"study_design_scores_gemma":[0.0003789231,0.001698172,0.001791887,0.00003520509,0.00006768792,0.0006829753,0.00001595373,0.002342626,0.9648438,0.0003120687,0.02781311,0.00001787029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9316177,0.02720868,0.01734431,0.001142411,0.000380147,0.0005000676,0.00147278,0.000490689,0.01984322],"genre_scores_gemma":[0.9695705,0.008401678,0.01127005,0.0005011085,0.0000842824,0.0002307408,0.001133868,0.00004299505,0.008764969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886063,"threshold_uncertainty_score":0.006309509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04213815704339693,"score_gpt":0.2949689461238029,"score_spread":0.252830789080406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}