{"id":"W4387957886","doi":"10.1101/2023.10.25.563974","title":"<i>Streptococcus pyogenes</i> Cas9 ribonucleoprotein delivery for efficient, rapid and marker-free gene editing in <i>Trypanosoma</i> and <i>Leishmania</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"CHIST-ERA; Canadian Institutes of Health Research; Université de Bordeaux; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; Alliance Française contre les Maladies Parasitaires","keywords":"Biology; Cas9; Trypanosoma brucei; CRISPR; Trypanosoma cruzi; Genome editing; Leishmania; Plasmid; Gene; Virology; Genome; Streptococcus pyogenes; Leishmania major; Guide RNA; Trypanosoma; Genetics; Computational biology; Parasite hosting; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048988,0.0002387308,0.0002051618,0.000132613,0.0001334044,0.000313128,0.0002897857,0.0003183715,0.001308414],"category_scores_gemma":[0.0001536229,0.0001495404,0.0001771474,0.0001070238,0.0002226249,0.0001817668,0.0002812443,0.0005945814,0.0005693218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979201,"about_ca_system_score_gemma":0.0002149304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007837177,"about_ca_topic_score_gemma":0.000812151,"domain_scores_codex":[0.9998395,0.00002891105,0.00001685187,0.00003676432,0.00005787178,0.0000200685],"domain_scores_gemma":[0.9999195,0.00001478337,0.00002805899,0.0000120741,0.000008841159,0.00001673597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003328699,0.000007856677,0.00005432669,0.00005196734,0.000004902494,0.00004664097,0.00001766246,0.0001611977,0.9970336,0.0004250195,0.0002698051,0.001893746],"study_design_scores_gemma":[0.000006994348,0.00005230889,0.0004039981,0.000006515589,0.00000834431,0.0002371784,0.00001085375,0.002556841,0.9867203,0.00007581914,0.00991315,0.000007632075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8797246,0.003452634,0.101875,0.0005640601,0.0002461108,0.0002230074,0.001456562,0.001510907,0.01094714],"genre_scores_gemma":[0.9573075,0.001232726,0.02972987,0.0001097983,0.00002457204,0.0001043798,0.00124954,0.0001913057,0.01005036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308414,"threshold_uncertainty_score":0.004377067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222878500224553,"score_gpt":0.2467477022768089,"score_spread":0.2245189172745633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}