{"id":"W4387957973","doi":"10.3390/cells12212528","title":"The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Methyltransferase; Biology; DNA methyltransferase; Cancer research; Methylation; DNMT3B; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003098548,0.0005629188,0.0008065938,0.001717367,0.0002146162,0.0006353674,0.0005288881,0.0007380437,0.003052282],"category_scores_gemma":[0.0005225149,0.0001684891,0.0003691074,0.001560937,0.0002355444,0.0009065856,0.0004816334,0.001040243,0.001412058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004929052,"about_ca_system_score_gemma":0.001045843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008858496,"about_ca_topic_score_gemma":0.001697179,"domain_scores_codex":[0.9998839,0.00001901796,0.00001872192,0.00002162742,0.00004452225,0.00001213699],"domain_scores_gemma":[0.9998336,0.00006506741,0.00002335663,0.000004414523,0.00005376374,0.00001984438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007730958,0.00003758061,0.0002783308,0.01503307,0.00009296095,0.0003907197,0.0000700606,0.000351441,0.002881598,0.002947513,0.03974063,0.9380987],"study_design_scores_gemma":[0.00001235511,0.00007510555,0.00107768,0.002712566,0.0001311228,0.002871981,0.00004679822,0.00009516296,0.0006164114,0.001464961,0.9908784,0.00001752071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001345347,0.9982109,0.0001467157,0.000267158,0.0002313147,0.000003080176,0.00002163733,0.000008428763,0.0009762028],"genre_scores_gemma":[0.0007422374,0.9979304,0.0001866282,0.0001899565,0.0001784083,0.000004203467,0.00003829693,0.000001897007,0.0007279579],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003052282,"threshold_uncertainty_score":0.01021093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399612648288053,"score_gpt":0.2458144527041643,"score_spread":0.2318183262212837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}