{"id":"W4387957973","doi":"10.3390/cells12212528","title":"The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Methyltransferase; Biology; DNA methyltransferase; Cancer research; Methylation; DNMT3B; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452833,0.0001874759,0.0006292438,0.00007244206,0.00004291063,0.00001363334,0.00008264666,0.0002281675,0.000001251028],"category_scores_gemma":[0.00002433849,0.0001359644,0.0002670947,0.0000851861,0.0001293894,0.000002539895,0.00007476998,0.00005622208,4.079502e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005140097,"about_ca_system_score_gemma":0.00005566287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003034051,"about_ca_topic_score_gemma":0.00000680345,"domain_scores_codex":[0.9988347,0.0001731532,0.0004214244,0.0002934982,0.0001491111,0.0001281166],"domain_scores_gemma":[0.9994326,0.00005307431,0.000142157,0.0002892339,0.00004094722,0.00004197086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008134205,0.00007596613,0.000104072,0.003769126,0.0003100293,0.00001190281,0.00002062466,0.00003256385,0.3459139,0.00001406845,0.000004181023,0.6496622],"study_design_scores_gemma":[0.001472354,0.0004297285,0.003223392,0.004893672,0.003153363,0.00006643035,0.0001364737,0.000448928,0.3929964,0.001104411,0.5909525,0.001122427],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1578496,0.8415819,0.00003689431,0.000001811231,0.00009453535,0.0003068791,0.0001155134,0.000002250832,0.00001056526],"genre_scores_gemma":[0.10249,0.8972064,0.00003007835,0.000001538877,0.0001127423,0.00001931979,0.00009406747,0.00003189308,0.00001391466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6485398,"threshold_uncertainty_score":0.5544466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399612648288053,"score_gpt":0.2458144527041643,"score_spread":0.2318183262212837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}