{"id":"W4387965047","doi":"10.1002/mds.29642","title":"A Randomized Phase 3 Study Comparing <scp>P2B001</scp> to its Components (Low‐Dose Extended‐Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended‐Release Pramipexole in Early Parkinson's Disease","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Pramipexole; Rasagiline; Parkinson's disease; Medicine; Pharmacology; Clinical endpoint; Levodopa; Randomized controlled trial; Internal medicine; Urology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002491237,0.002049044,0.003014107,0.0005044244,0.0006646908,0.00119986,0.001245383,0.002138553,0.01040845],"category_scores_gemma":[0.002097189,0.00101127,0.001470433,0.0004846917,0.00167392,0.00145864,0.0004972556,0.003545206,0.001581427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009751488,"about_ca_system_score_gemma":0.002515108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123458,"about_ca_topic_score_gemma":0.00269637,"domain_scores_codex":[0.9992027,0.0004228774,0.00003815843,0.0001590094,0.00006798747,0.0001093694],"domain_scores_gemma":[0.9984239,0.0004660572,0.0003259655,0.0001337229,0.0001174509,0.0005328487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9760703,0.01303695,0.0002231389,0.0002678275,0.0003469972,0.00002873146,0.00003639892,0.0002304031,0.002804687,0.00009224912,0.0006840597,0.006178176],"study_design_scores_gemma":[0.9134934,0.08484317,0.0006111292,0.0000108057,0.0001112808,0.00002204502,0.00000987546,0.0002499948,0.000224093,0.00009573555,0.0003186154,0.000009811596],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745354,0.00205386,0.001397832,0.000670428,0.0006565162,0.01532297,0.002063358,0.0002871158,0.003012513],"genre_scores_gemma":[0.9666876,0.001631296,0.003653299,0.001400235,0.0005317958,0.01860963,0.001605499,0.00006046687,0.005820208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040845,"threshold_uncertainty_score":0.03481978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042136471165548,"score_gpt":0.2930300121642068,"score_spread":0.2726086474525513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}