{"id":"W4387965047","doi":"10.1002/mds.29642","title":"A Randomized Phase 3 Study Comparing <scp>P2B001</scp> to its Components (Low‐Dose Extended‐Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended‐Release Pramipexole in Early Parkinson's Disease","year":2023,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"","keywords":"Pramipexole; Rasagiline; Parkinson's disease; Medicine; Pharmacology; Clinical endpoint; Levodopa; Randomized controlled trial; Internal medicine; Urology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001128843,0.0007941969,0.00186653,0.001110951,0.0002019633,0.0001069125,0.00024418,0.0001047351,0.00004914203],"category_scores_gemma":[0.0012833,0.0007292695,0.0002674226,0.001169141,0.000145763,0.0002510234,0.0004739031,0.0002530024,0.00004036392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001439091,"about_ca_system_score_gemma":0.0001329362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000586201,"about_ca_topic_score_gemma":0.0001347165,"domain_scores_codex":[0.9949054,0.0006037484,0.001129308,0.001369437,0.0009993557,0.0009927222],"domain_scores_gemma":[0.9965763,0.0005536427,0.0003206854,0.000725561,0.0001549587,0.001668838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4691531,0.06947984,0.3764313,0.002067921,0.004679167,0.003418475,0.009003324,0.003831148,0.01047622,0.0002913056,0.001891497,0.04927667],"study_design_scores_gemma":[0.3966797,0.001607704,0.5645887,0.0005606216,0.0009598496,9.416236e-7,0.002224642,0.03162607,0.0004272368,0.0005456927,0.0003935049,0.0003853166],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986999,0.001034271,0.0003398655,0.000800998,0.0001455164,0.01010635,0.0002211588,0.0001830536,0.0001697296],"genre_scores_gemma":[0.9948642,0.0007696493,0.0005848599,0.0009436446,0.00003126152,0.001827986,0.0002273255,0.0001111606,0.0006398947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1881574,"threshold_uncertainty_score":0.9995158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042136471165548,"score_gpt":0.2930300121642068,"score_spread":0.2726086474525513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}