{"id":"W4387965670","doi":"10.1038/s41389-023-00492-0","title":"Molecular mechanisms in colitis-associated colorectal cancer","year":2023,"lang":"en","type":"review","venue":"Oncogenesis","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; U.S. Department of Health and Human Services; AbbVie Canada; National Institutes of Health; Regeneron Pharmaceuticals; Eli Lilly and Company","keywords":"Field cancerization; Epigenetics; Carcinogenesis; Colorectal cancer; Inflammatory bowel disease; Biology; Pathogenesis; Mouse model of colorectal and intestinal cancer; Cancer research; Context (archaeology); Cancer; Disease; KRAS; Bioinformatics; Medicine; Immunology; Genetics; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422236,0.0005364809,0.0007824196,0.001424004,0.0001985483,0.0006209607,0.0004892666,0.0006671819,0.002033522],"category_scores_gemma":[0.0003067153,0.0001458257,0.0003042827,0.00119692,0.0003537148,0.0006030147,0.0004528061,0.001059844,0.0009885125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708428,"about_ca_system_score_gemma":0.0006419582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006322676,"about_ca_topic_score_gemma":0.001184916,"domain_scores_codex":[0.9999121,0.00001391263,0.00001217199,0.00001632538,0.00003324261,0.00001220224],"domain_scores_gemma":[0.9998971,0.00004044193,0.00001976891,0.000003878345,0.00002752235,0.00001120536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009535769,0.00006809651,0.0005081906,0.02085236,0.0001256317,0.0005083004,0.00008446266,0.0005280052,0.006557315,0.00628993,0.02267214,0.9417102],"study_design_scores_gemma":[0.00001484154,0.0001020881,0.002237434,0.003119115,0.0001333269,0.002823774,0.00006659278,0.00009775407,0.001298433,0.002902379,0.9871848,0.00001927954],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001617478,0.9988723,0.00007501904,0.0001691953,0.0001004803,0.000002402945,0.00001264076,0.000005531539,0.0006006276],"genre_scores_gemma":[0.0008909028,0.9984927,0.00007823494,0.00009510416,0.00007728419,0.000002929635,0.00002532861,7.003778e-7,0.0003367501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002033522,"threshold_uncertainty_score":0.006802857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06234820072534254,"score_gpt":0.3710494475942608,"score_spread":0.3087012468689183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}