{"id":"W4387966581","doi":"10.21873/cgp.20404","title":"Molecular Characteristics and Therapeutic Vulnerabilities of Claudin-low Breast Cancers Derived from Cell Line Models","year":2023,"lang":"en","type":"article","venue":"Cancer Genomics & Proteomics","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Essar Steel Algoma (Canada); Sault Area Hospital; NOSM University","funders":"","keywords":"Cancer research; Cell culture; Biology; Claudin; Estrogen receptor; Breast cancer; Wnt signaling pathway; Cancer; Cell biology; Signal transduction; Genetics; Tight junction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308199,0.0002614011,0.0002667283,0.0004687743,0.0002284494,0.000487138,0.0002383776,0.0003601038,0.001708141],"category_scores_gemma":[0.0002523149,0.0001056317,0.0003154901,0.0003389644,0.0001684446,0.000174763,0.000183001,0.0007503247,0.0005486023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003861737,"about_ca_system_score_gemma":0.0001675311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009309474,"about_ca_topic_score_gemma":0.001059281,"domain_scores_codex":[0.9997874,0.00002597189,0.00002498305,0.00004366689,0.00008351966,0.00003442847],"domain_scores_gemma":[0.9997787,0.00004791183,0.00004900048,0.00003712543,0.00005131535,0.00003597682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131503,0.00007908453,0.001313396,0.00006546429,0.00001364233,0.0001247465,0.00003810989,0.0001742047,0.9961458,0.0001327365,0.0002080568,0.001573275],"study_design_scores_gemma":[0.00002745891,0.0008897091,0.01387615,0.00001149013,0.00008848103,0.001028408,0.0001351097,0.001690736,0.9744599,0.0001087881,0.007669121,0.0000145685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887843,0.001989449,0.004656571,0.0002010894,0.00003348235,0.00007246237,0.002465956,0.0001909712,0.001605639],"genre_scores_gemma":[0.986459,0.001342146,0.002663652,0.0001020558,0.000007468794,0.0001096755,0.006050004,0.00005463643,0.003211312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708141,"threshold_uncertainty_score":0.005714357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804987791097204,"score_gpt":0.2487364739727974,"score_spread":0.2206865960618253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}