{"id":"W4387966939","doi":"10.7554/elife.81406","title":"Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Candida albicans; Transcriptome; Biology; Downregulation and upregulation; Corpus albicans; Cell biology; Antifungal drug; Ribosome; Ribosomal protein; Fluconazole; Gene; Cell; Microbiology; Gene expression; RNA; Genetics; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152205,0.0002344859,0.0002857358,0.0002702866,0.0002389455,0.0005376055,0.0001461017,0.0003427557,0.0004860842],"category_scores_gemma":[0.0001671585,0.0001335016,0.0002451272,0.0002720057,0.0001966299,0.0001581767,0.0003214883,0.0004719716,0.0001865302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200609,"about_ca_system_score_gemma":0.000194038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008290274,"about_ca_topic_score_gemma":0.001335926,"domain_scores_codex":[0.9997906,0.00001338917,0.00001717934,0.00005871246,0.00006249754,0.0000576683],"domain_scores_gemma":[0.9998583,0.00001861848,0.00003747323,0.00002243905,0.00003351421,0.00002973618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004767382,0.000008605878,0.0008232633,0.000008824683,0.000002048544,0.00002082274,0.00001465376,0.00003416328,0.9979802,0.00002676568,0.00002009415,0.001012894],"study_design_scores_gemma":[0.00001412337,0.0003052418,0.1544017,0.00001280255,0.00001812335,0.000447262,0.0001888248,0.001570956,0.8409409,0.0002298793,0.001845982,0.00002422674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996204,0.0004257747,0.001594048,0.00006672154,0.000006954474,0.00002138106,0.0007588316,0.0000753695,0.0008468366],"genre_scores_gemma":[0.9946705,0.0003805998,0.002539404,0.0001290722,0.000008024573,0.00006268833,0.001002319,0.0000246193,0.001182739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008290274,"threshold_uncertainty_score":0.001648426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591121448631351,"score_gpt":0.3096759707834372,"score_spread":0.2737647562971237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}