{"id":"W4387966939","doi":"10.7554/elife.81406","title":"Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Candida albicans; Transcriptome; Biology; Downregulation and upregulation; Corpus albicans; Cell biology; Antifungal drug; Ribosome; Ribosomal protein; Fluconazole; Gene; Cell; Microbiology; Gene expression; RNA; Genetics; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542234,0.0001747864,0.0003427183,0.0001560605,0.0001756219,0.00002490378,0.00006889932,0.00008639814,0.00007184102],"category_scores_gemma":[0.0004062461,0.0001524928,0.00007586925,0.0004331616,0.0001292637,0.0000503861,0.00009123243,0.0001884701,0.0001985231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009624644,"about_ca_system_score_gemma":0.0001558365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002313034,"about_ca_topic_score_gemma":0.0004363491,"domain_scores_codex":[0.9984891,0.00008918388,0.0002140887,0.0004517003,0.0003896817,0.0003662224],"domain_scores_gemma":[0.999016,0.0001814507,0.000038539,0.0003146929,0.0001411187,0.0003082083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0181521,0.0003470826,0.6206173,0.0002450033,0.0004696271,0.0028266,0.00543852,0.00004624044,0.3155728,0.0004189285,0.02455082,0.01131489],"study_design_scores_gemma":[0.001015409,0.001237915,0.9494969,0.0001549822,0.00005208299,0.0001059224,0.0009632635,0.0002524863,0.04008425,0.0000651664,0.00629412,0.0002775171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962783,0.0002098301,0.0001750337,0.0008046814,0.00009624531,0.0005859401,0.00007543922,0.0001781591,0.001596381],"genre_scores_gemma":[0.9939627,0.00006509994,0.0002822544,0.0009658595,0.0001362731,0.00003956076,0.0000121691,0.00002592388,0.004510136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3288795,"threshold_uncertainty_score":0.6218477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591121448631351,"score_gpt":0.3096759707834372,"score_spread":0.2737647562971237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}