{"id":"W4387967287","doi":"10.1093/jmcb/mjad062","title":"The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm","year":2023,"lang":"en","type":"article","venue":"Journal of Molecular Cell Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Universitätsklinikum Köln; Deutsche Forschungsgemeinschaft","keywords":"Cytokine storm; Proinflammatory cytokine; Immunology; Chemokine; Immune system; ARDS; Medicine; Cytokine; Inflammation; Lung; Biology; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007357555,0.0003012866,0.0001633485,0.00008876142,0.00009137393,0.0001195476,0.00009137472,0.0002970214,0.001390198],"category_scores_gemma":[0.00007409658,0.00007239573,0.0001983922,0.0000726959,0.0001171062,0.00009107339,0.0001494578,0.0003178995,0.000444283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188077,"about_ca_system_score_gemma":0.0001063448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001473673,"about_ca_topic_score_gemma":0.0001450389,"domain_scores_codex":[0.9999194,0.00001668755,0.000005697093,0.00001564532,0.00001944801,0.00002308742],"domain_scores_gemma":[0.9999714,0.000004947746,0.000007760281,0.000003433887,0.000004386236,0.000008016375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085658,0.00002784314,0.0002126999,0.00003250583,0.00000303906,0.0001294445,0.000006218625,0.00002314145,0.9982679,0.00003990929,0.00006844061,0.001080181],"study_design_scores_gemma":[0.00008081841,0.0007999993,0.01414401,0.00001167792,0.00001857426,0.002009518,0.00004445197,0.0008056251,0.9705892,0.00009356531,0.01139772,0.000004934489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928884,0.002767069,0.001785408,0.0001934593,0.00008072231,0.00003612681,0.0002655799,0.00004213931,0.001941088],"genre_scores_gemma":[0.993662,0.001089118,0.00161806,0.0001811835,0.00004029044,0.00003408423,0.000852649,0.00001063174,0.002511966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390198,"threshold_uncertainty_score":0.004650652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132748431414566,"score_gpt":0.3227560157924614,"score_spread":0.2914285314783158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}