{"id":"W4387975888","doi":"10.3390/cancers15215168","title":"Heparan-6-O-Endosulfatase 2 Promotes Invasiveness of Head and Neck Squamous Carcinoma Cell Lines in Co-Cultures with Cancer-Associated Fibroblasts","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Akademie Věd České Republiky","keywords":"Basal cell; Head and neck squamous-cell carcinoma; Cell culture; Cancer; Cancer research; Head and neck; Cancer-Associated Fibroblasts; Medicine; Head and neck cancer; Pathology; Cancer cell; Biology; Internal medicine; Surgery; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277405,0.0002985593,0.0002202258,0.0001881245,0.0001487705,0.0001946041,0.0001126674,0.0001412852,0.0009749964],"category_scores_gemma":[0.00006516716,0.0001157484,0.0002733743,0.0001194973,0.0001177358,0.0001304306,0.0001553407,0.000343245,0.0002059241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135701,"about_ca_system_score_gemma":0.0002692963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004686949,"about_ca_topic_score_gemma":0.007842558,"domain_scores_codex":[0.9998785,0.00002086102,0.00001195201,0.00001900347,0.0000395399,0.00003007406],"domain_scores_gemma":[0.9999317,0.00001405111,0.00001049978,0.00001199704,0.000009125851,0.00002263088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007024295,0.00005141981,0.0003097793,0.00002043582,0.000005422653,0.00004580225,0.00002307664,0.00003708363,0.9987404,0.00002354851,0.00004954109,0.0006232499],"study_design_scores_gemma":[0.00001182083,0.0005613995,0.0114728,0.000004388632,0.00001815246,0.0001697023,0.00006256935,0.0009632216,0.9853132,0.00001080257,0.001408119,0.000003719309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980891,0.0004804654,0.000387537,0.00003185903,0.00001162707,0.00001800619,0.0001432338,0.00002310886,0.0008150403],"genre_scores_gemma":[0.9956749,0.0003945864,0.0008326604,0.00002640478,0.000005635816,0.00002620664,0.0003819404,0.000006131726,0.002651585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004686949,"threshold_uncertainty_score":0.009319365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593376935529179,"score_gpt":0.2964508142216081,"score_spread":0.2805170448663163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}