{"id":"W4387978061","doi":"10.1016/j.yexcr.2023.113824","title":"GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner","year":2023,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China","keywords":"Chondrocyte; Biology; Protein kinase B; Cell biology; PI3K/AKT/mTOR pathway; Cellular differentiation; Signal transduction; Protein phosphatase 2; Cartilage; Phosphatase; Phosphorylation; Anatomy; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565363,0.0001110712,0.0002609257,0.0003743366,0.00006184542,0.00001117979,0.00007247767,0.00008430226,0.0001279589],"category_scores_gemma":[0.00002310421,0.00009876073,0.00007407836,0.0006772337,0.00007081272,0.0001138943,0.00007851528,0.0001515154,0.00003352654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129602,"about_ca_system_score_gemma":0.00005135777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001105524,"about_ca_topic_score_gemma":0.000006365054,"domain_scores_codex":[0.9984906,0.00008284952,0.0002937807,0.0002461114,0.0005799167,0.0003066807],"domain_scores_gemma":[0.9995157,0.00008246444,0.00006013832,0.0001982587,0.00009220656,0.00005128651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002608299,0.0005669582,0.001527596,0.0001273818,0.00001073574,0.00002340494,0.002275736,0.00002308122,0.9942844,0.0001192306,0.00002048792,0.0007601855],"study_design_scores_gemma":[0.002729085,0.002207728,0.001828014,0.0002301654,0.000007148088,0.000002192068,0.001713125,0.001650943,0.9892768,0.0002734165,0.00001141156,0.00006997414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964486,0.0007260226,0.000008890585,0.00003879557,0.00005789121,0.0008795949,0.00000381183,0.00002367503,0.001812666],"genre_scores_gemma":[0.997784,0.00005322611,0.0004149093,0.000003391719,0.00003822261,0.0001324815,0.00009090425,0.00002566445,0.001457169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005007576,"threshold_uncertainty_score":0.4027346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0620978363502073,"score_gpt":0.3643877962925922,"score_spread":0.3022899599423849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}