{"id":"W4387978301","doi":"10.1016/j.jhep.2023.10.029","title":"Adeno-associated viruses for gene therapy – clinical implications and liver-related complications, a guide for hepatologists","year":2023,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Medicine; Adeno-associated virus; Hepatology; Liver disease; Factor IX; Bioinformatics; Gene; Internal medicine; Vector (molecular biology); Biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001965517,0.0003780448,0.001786685,0.000279844,0.000201016,0.0000327932,0.000725863,0.001043745,0.000005839896],"category_scores_gemma":[0.001513704,0.0003119188,0.001063375,0.0002373423,0.0003042339,0.000005774355,0.0001313459,0.0003981687,0.000009516875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007617706,"about_ca_system_score_gemma":0.001335434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001096453,"about_ca_topic_score_gemma":0.0001324806,"domain_scores_codex":[0.9961181,0.000726449,0.002006559,0.000548195,0.0001381494,0.0004625775],"domain_scores_gemma":[0.9954877,0.001196945,0.001750464,0.0005575408,0.0008153891,0.0001919249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001807678,0.0007648098,0.002497568,0.001769155,0.00655119,0.00002212729,0.00002404786,0.000002985549,0.002448078,0.0002794716,0.05891427,0.9249186],"study_design_scores_gemma":[0.001874256,0.004797264,0.0001449322,0.0003348555,0.0004856501,0.0005304866,0.000004164616,0.00002535714,0.0002829114,0.0006041927,0.9905811,0.000334812],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006785632,0.9891796,0.0007343038,0.0006242578,0.0002930512,0.001806813,0.0005439412,0.00002177626,0.0000106079],"genre_scores_gemma":[0.0003660208,0.9964408,0.001264803,0.0003644738,0.0002748657,0.0004649065,0.0005480904,0.0001157593,0.0001602957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9316669,"threshold_uncertainty_score":0.9999333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2328272792737944,"score_gpt":0.4917770861110857,"score_spread":0.2589498068372914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}