{"id":"W4387979166","doi":"10.1183/13993003.congress-2023.oa1575","title":"A multi-omics approach identifies that human antigen R (HuR) controls multiple cellular pathways in idiopathic pulmonary fibrosis (IPF) pathogenesis","year":2023,"lang":"en","type":"article","venue":"","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Idiopathic pulmonary fibrosis; Myofibroblast; Pathogenesis; Proteomics; Pulmonary fibrosis; Medicine; Cancer research; RNA-binding protein; Extracellular matrix; Gene knockdown; Fibrosis; RNA; Biology; Lung; Pathology; Immunology; Cell biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008558147,0.000853292,0.001212422,0.001829795,0.0008618741,0.001952034,0.0004537862,0.0006753339,0.002015138],"category_scores_gemma":[0.0006789552,0.0003176387,0.00154472,0.00156079,0.0003492544,0.0007611387,0.0008940818,0.0009616265,0.00067695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007897,"about_ca_system_score_gemma":0.0009035453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001852832,"about_ca_topic_score_gemma":0.003473745,"domain_scores_codex":[0.9994373,0.00007443069,0.00004236923,0.0002314284,0.000144092,0.00007035386],"domain_scores_gemma":[0.9996538,0.00008843316,0.00009268662,0.00004836282,0.00006775738,0.00004884111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087928,0.0002405415,0.06733778,0.002345401,0.001165905,0.0007087736,0.0003394751,0.005587613,0.8218772,0.003674647,0.01080759,0.0848271],"study_design_scores_gemma":[0.0002004911,0.001189479,0.5545908,0.001072424,0.002740586,0.00258803,0.001623065,0.1183479,0.1906213,0.02171682,0.1050215,0.000287641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7747266,0.03829786,0.09142724,0.006966205,0.0007470176,0.0004453182,0.06703545,0.003973236,0.01638102],"genre_scores_gemma":[0.8323242,0.01702659,0.09438992,0.003934246,0.0003425519,0.000558668,0.04688321,0.0003078482,0.004232715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002015138,"threshold_uncertainty_score":0.006741345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04333066782845962,"score_gpt":0.2628519670931089,"score_spread":0.2195212992646493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}