{"id":"W4387996465","doi":"10.1186/s13148-023-01564-z","title":"Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts","year":2023,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University Health Centre; University of Calgary; University of Ottawa; Canadian Nuclear Laboratories","funders":"Génome Québec","keywords":"dNaM; DNA methylation; Epigenetics; Carcinogenesis; DNA damage; Biology; Cancer research; Molecular biology; Chemistry; Genetics; Gene; DNA; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006655639,0.0001447329,0.0005170385,0.0001555813,0.00007108726,0.00001750777,0.00008809466,0.000252728,0.00002317535],"category_scores_gemma":[0.002772313,0.0001313918,0.0001239531,0.0003281467,0.0002231199,0.00005879979,0.00005606831,0.0002650822,0.00004293683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003420584,"about_ca_system_score_gemma":0.00009325108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001182527,"about_ca_topic_score_gemma":0.00001270381,"domain_scores_codex":[0.9982541,0.000200055,0.0007683226,0.0003150103,0.0002456936,0.0002167808],"domain_scores_gemma":[0.9963493,0.002697367,0.0002982913,0.0002983159,0.0001353731,0.0002213046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002987245,0.0001754873,0.9685272,0.0001645298,0.0001419896,0.000003399814,0.0001128345,0.00003050995,0.004676408,0.00002477289,0.0005508765,0.02556212],"study_design_scores_gemma":[0.001298337,0.0008339341,0.9858142,0.00008567212,0.0002327576,0.000001525158,0.00004202703,0.009105635,0.001782388,0.0002348498,0.0004495569,0.0001191756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954182,0.0003557026,0.002144917,0.001092157,0.0002873559,0.0005039832,0.00003145236,0.00009931091,0.00006695339],"genre_scores_gemma":[0.9933997,0.0004986154,0.005184535,0.00008631971,0.0003610152,0.00001348683,0.00005915511,0.0000274962,0.0003696135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02544294,"threshold_uncertainty_score":0.5358003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197191834941257,"score_gpt":0.4125857579237409,"score_spread":0.2928665744296152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}