{"id":"W4387997190","doi":"10.21203/rs.3.rs-3487637/v1","title":"Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Alex's Lemonade Stand Foundation for Childhood Cancer; U.S. Department of Defense","keywords":"Genetically engineered; Fusion protein; Fusion gene; Fusion; Genetically modified organism; Virology; Biology; Cancer research; Molecular biology; Computational biology; Recombinant DNA; Genetics; Gene; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484069,0.0004813534,0.0003088927,0.0008622849,0.0002107994,0.0006234183,0.0003884694,0.0007804552,0.002726034],"category_scores_gemma":[0.0002300193,0.0003044852,0.000278272,0.0003051557,0.0004699863,0.0003586233,0.0003132677,0.0009610526,0.0008897196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006027978,"about_ca_system_score_gemma":0.0003128776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009917435,"about_ca_topic_score_gemma":0.0008219234,"domain_scores_codex":[0.9996543,0.00005730903,0.00003144345,0.00007482524,0.0001174625,0.00006463085],"domain_scores_gemma":[0.9997682,0.00004605918,0.00007060418,0.00004136116,0.00002033059,0.00005345593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347729,0.00003903156,0.0001427981,0.00002586603,0.000008145406,0.0001008422,0.00002658028,0.000308515,0.9970216,0.001184664,0.0001242323,0.0008829086],"study_design_scores_gemma":[0.00002183992,0.0001206748,0.0005401906,0.000004895596,0.00001379445,0.0002918158,0.00002273514,0.001845728,0.9931346,0.0001103761,0.003889689,0.000003695474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778006,0.0008313452,0.01340891,0.000253647,0.0001271639,0.000118926,0.001244212,0.000359707,0.005855531],"genre_scores_gemma":[0.9771498,0.0006578669,0.007755353,0.00004725745,0.00001746223,0.00009286746,0.0009956466,0.0001255829,0.01315824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002726034,"threshold_uncertainty_score":0.009119511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1362611783455599,"score_gpt":0.3982143401843724,"score_spread":0.2619531618388125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}