{"id":"W4388001603","doi":"10.1101/2023.10.27.564195","title":"ATR promotes mTORC1 activity via <i>de novo</i> cholesterol synthesis","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institutes of Health; Ovarian Cancer Research Alliance; Melanoma Research Alliance","keywords":"mTORC1; Chemistry; Cell biology; Cancer research; Cancer; Cancer cell; Biology; Genetics; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173916,0.000317982,0.0002958505,0.0003016732,0.0002181424,0.0004781983,0.0001962638,0.0002293372,0.004108292],"category_scores_gemma":[0.0001353525,0.0001384077,0.0002061127,0.0002262201,0.0002930181,0.0002764208,0.0003902849,0.0005310076,0.002225511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003243202,"about_ca_system_score_gemma":0.000204202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003616952,"about_ca_topic_score_gemma":0.0004722648,"domain_scores_codex":[0.9998599,0.00002019979,0.00001076863,0.00003258849,0.00004790933,0.00002864203],"domain_scores_gemma":[0.9999076,0.00001560306,0.00002516884,0.00001978883,0.00001320259,0.00001862476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001012354,0.00001371604,0.0001979346,0.00006193737,0.000004682317,0.00009859315,0.00001033288,0.0001029179,0.9971076,0.0004448362,0.0002622722,0.001593911],"study_design_scores_gemma":[0.00001491327,0.00003711137,0.002825145,0.000008716914,0.000005834472,0.0001930719,0.0000167157,0.00101176,0.9901068,0.0002417481,0.00553449,0.000003813396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9451147,0.004958142,0.0210433,0.001219681,0.0002665232,0.00006674317,0.002684303,0.001320679,0.02332602],"genre_scores_gemma":[0.9732707,0.00215986,0.006715493,0.0001383581,0.00007665413,0.000026894,0.001290224,0.000273796,0.01604803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004108292,"threshold_uncertainty_score":0.01374358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868525552600714,"score_gpt":0.2296541666155952,"score_spread":0.210968911089588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}